Glucosidase-Inhibitors-Modulators-MCE

1、 HYPERLINK https:/www.MedChemE/Targets/Glucosidase.html GlucosidaseGlucosidases are glycoside hydrolase enzymes. -glucosidase is a glucosidase located in the brush border of the small intestinethat acts upon (14) bonds. -Glucosidase inhibitor is a new type of antidiabetics. By reducing the postprand

2、ial blood sugarconcentration, it can effectively control the blood sugar levels, thereby reducing the occurrence of diabetic complications.-glucosidase catalyzes the hydrolysis of the glycosidic bonds to terminal non-reducing residues in -D-glucosides andoligosaccharides, with release of glucose. -G

3、lucosidase has attracted substantial attention in the scientific community because ofits pivotal role in cellulose degradation, glycoside transformation and many other industrial processes. -glucosidases catalyze thefinal step of cellulose hydrolysis and are essential in cellulose degradation.www.Me

4、dChemE 1 HYPERLINK https:/www.MedChemE/Targets/Glucosidase.html Glucosidase HYPERLINK https:/www.MedChemE/Targets/Glucosidase.html HYPERLINK https:/www.MedChemE/Targets/Glucosidase.html Inhibitors, HYPERLINK https:/www.MedChemE/Targets/Glucosidase.html HYPERLINK https:/www.MedChemE/Targets/Glucosida

5、se.html Activators HYPERLINK https:/www.MedChemE/Targets/Glucosidase.html HYPERLINK https:/www.MedChemE/Targets/Glucosidase.html & HYPERLINK https:/www.MedChemE/Targets/Glucosidase.html HYPERLINK https:/www.MedChemE/Targets/Glucosidase.html Modulators HYPERLINK https:/www.MedChemE/plus-afzelechin.ht

6、ml (+)-AfzelechinCat. No.: HY-N2821 HYPERLINK https:/www.MedChemE/z-3-butylidenephthalide.html (Z)-3-Butylidenephthalide(Z)-Butylidenephthalide) Cat. No.: HY-N0336A(+)-Afzelechin, isolated from rhizomes of Bergenialigulata, is an alpha-glucosidase activity inhibitorwith an ID (50% inhibition dose) v

7、alue of 0.1350mM. (+)-Afzelechin can delay the absorption ofcarbohydrates in food to suppress postprandialhyperglycemia and hyperinsulinemia.(Z)-3-Butylidenephthalide is anantihyperglycemic agent by inhibiting theactivity of intestinal and yeast R-glucosidases(IC =2.35 mM; K=4.86 mM).50 iPurity: 98.

8、0%Clinical Data: No Development ReportedSize: 5 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/1-Deoxynojirimycin.html 1-Deoxynojirimycin(Duvoglustat) Cat. No.: HY-14860 HYPERLINK https:/www.MedChemE/1-deoxynojirimycin-hydrochloride.html 1-Deoxynoji

9、rimycin HYPERLINK https:/www.MedChemE/1-deoxynojirimycin-hydrochloride.html HYPERLINK https:/www.MedChemE/1-deoxynojirimycin-hydrochloride.html hydrochloride(Duvoglustat hydrochloride) Cat. No.: HY-14860A1-Deoxynojirimycin (Duvoglustat) is a potent andorally active -glucosidase inhibitor.1-Deoxynoji

10、rimycin suppresses postprandial bloodglucose and is widely used for diabetes mellitus.1-Deoxynojirimycin possesses antihyperglycemic,anti-obesity, and antiviral features.1-Deoxynojirimycin hydrochloride (Duvoglustathydrochloride) is a potent and orally active-glucosidase inhibitor. 1-Deoxynojirimyci

11、nhydrochloride suppresses postprandial bloodglucose and is widely used for diabetes mellitus.Purity: 98.0%Clinical Data: Phase 2Size: 10 mM 1 mL, 5 mg, 10 mg, 25 mg, 50 mgPurity: 98%Clinical Data: Phase 2Size: 5 mg, 10 mg, 25 mg HYPERLINK https:/www.MedChemE/3,4-Dicaffeoylquinic-acid.html 3,4-Dicaff

12、eoylquinic HYPERLINK https:/www.MedChemE/3,4-Dicaffeoylquinic-acid.html HYPERLINK https:/www.MedChemE/3,4-Dicaffeoylquinic-acid.html acid(3,4-Di-O-caffeoylquinic acid; Isochlorogenic acid B) Cat. No.: HY-N0057 HYPERLINK https:/www.MedChemE/4_acute_,5-Dihydroxyflavone.html 4,5-DihydroxyflavoneCat. No

13、.: HY-N18813,4-Dicaffeoylquinic acid (3,4-Di-O-caffeoylquinicacid), naturally isolated from Laggera alata, hasantioxidative, DNA protective, neuroprotective andhepatoprotective properties.4,5-Dihydroxyflavone is a soybean LOX-1 andyeast -Glucosidase inhibitor, with an K of 102.6iM for soybean LOX-1

14、and an IC of 66 M for50yeast -glucosidase. LOX-1 isshort for Lectin-likeoxidized low-density lipoprotein receptor-1.Purity: 98.08%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 5 mg, 10 mgPurity: 95.46%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 10 mg, 25 mg, 50 mg, 100 mg HYPER

15、LINK https:/www.MedChemE/Acarbose.html Acarbose HYPERLINK https:/www.MedChemE/Acarbose.html HYPERLINK https:/www.MedChemE/acarbose-sulfate.html Acarbose HYPERLINK https:/www.MedChemE/acarbose-sulfate.html HYPERLINK https:/www.MedChemE/acarbose-sulfate.html sulfate(BAY g 5421) Cat. No.: HY-B0089 (Bay

16、-g 5421 sulfate) Cat. No.: HY-B0089AAcarbose (BAY g 5421), antihyperglycemic agent, isan orally active alpha-glucosidase inhibitor(IC =11 nM). Acarbose can potentiate the50hypoglycemic effects of sulfonylureas or insulin.Acarbose (BAY g 5421) sulfate, antihyperglycemicagent, is an orally active alph

17、a-glucosidaseinhibitor (IC =11 nM). Acarbose sulfate can50potentiate the hypoglycemic effects ofsulfonylureas or insulin.Purity: 98.0%Clinical Data: LaunchedSize: 10 mM 1 mL, 200 mg, 1 gPurity: 98%Clinical Data: LaunchedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/Afegostat.html Afegostat HYPERLIN

18、K https:/www.MedChemE/Afegostat.html HYPERLINK https:/www.MedChemE/Afegostat_D-Tartrate.html Afegostat HYPERLINK https:/www.MedChemE/Afegostat_D-Tartrate.html HYPERLINK https:/www.MedChemE/Afegostat_D-Tartrate.html D-Tartrate(D-Isofagomine; Isofagomine) Cat. No.: HY-14829 (D-Isofagomine D-Tartrate;

19、Isofagomine D-Tartrate) Cat. No.: HY-14829EAfegostat is a pharmacological chaperone, whichspecifically and reversibly bindsacid-glucosidase (GCase) in the endoplasmicreticulum (ER) with high affinity.Afegostat D-Tartrate is a pharmacologicalchaperone, which specifically and reversibly bindsacid-gluc

20、osidase (GCase) in the endoplasmicreticulum (ER) with high affinity.Purity: 98%Clinical Data: Phase 2Size: 1 mg, 5 mgPurity: 98.0%Clinical Data: Phase 2Size: 5 mg, 25 mg2 Tel: 609-228-6898 Fax: 609-228-5909 Email: salesMedChemE HYPERLINK https:/www.MedChemE/Ambroxol.html Ambroxol(NA-872) Cat. No.: H

21、Y-B1039 HYPERLINK https:/www.MedChemE/ambroxol-hydrochloride.html Ambroxol HYPERLINK https:/www.MedChemE/ambroxol-hydrochloride.html HYPERLINK https:/www.MedChemE/ambroxol-hydrochloride.html hydrochloride(NA-872 hydrochloride) Cat. No.: HY-B1039AAmbroxol (NA-872), an active metabolite of theprodrug

22、Bromhexine, has potent expectoranteffects. Ambroxol is a glucocerebrosidase (GCase)chaperone and increases glucocerebrosidaseactivity.Ambroxol hydrochloride (NA-872 hydrochloride), anactive metabolite of the prodrug Bromhexine, haspotent expectorant effects. Ambroxol hydrochlorideis a glucocerebrosi

23、dase (GCase) chaperone andincreases glucocerebrosidase activity.Purity: 99.83%Clinical Data: LaunchedSize: 10 mM 1 mL, 100 mgPurity: 98.0%Clinical Data: LaunchedSize: 10 mM 1 mL, 100 mg HYPERLINK https:/www.MedChemE/ambroxol-d5-hydrochloride.html Ambroxol-d5 HYPERLINK https:/www.MedChemE/ambroxol-d5

24、-hydrochloride.html HYPERLINK https:/www.MedChemE/ambroxol-d5-hydrochloride.html hydrochloride(NA-872-d5 hydrochloride) Cat. No.: HY-B1039AS HYPERLINK https:/www.MedChemE/bisabolone-oxide-a.html Bisabolone HYPERLINK https:/www.MedChemE/bisabolone-oxide-a.html HYPERLINK https:/www.MedChemE/bisabolone

25、-oxide-a.html oxide HYPERLINK https:/www.MedChemE/bisabolone-oxide-a.html HYPERLINK https:/www.MedChemE/bisabolone-oxide-a.html ACat. No.: HY-N8120Ambroxol-d5 (NA-872-d5) hydrochloride is thedeuterium labeled Ambroxol hydrochloride. Ambroxolhydrochloride (NA-872 hydrochloride), an activemetabolite o

26、f the prodrug Bromhexine, has potentexpectorant effects.Bisabolone oxide A is an -glucosidase inhibitor.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98%Clinical Data: No Development ReportedSize: 5 mg, 10 mg, 25 mg HYPERLINK https:/www.MedChemE/brevifolincarboxylic-acid.h

27、tml Brevifolincarboxylic HYPERLINK https:/www.MedChemE/brevifolincarboxylic-acid.html HYPERLINK https:/www.MedChemE/brevifolincarboxylic-acid.html acid HYPERLINK https:/www.MedChemE/brevifolincarboxylic-acid.html HYPERLINK https:/www.MedChemE/butyl-isobutyl-phthalate.html Butyl HYPERLINK https:/www.

28、MedChemE/butyl-isobutyl-phthalate.html HYPERLINK https:/www.MedChemE/butyl-isobutyl-phthalate.html isobutyl HYPERLINK https:/www.MedChemE/butyl-isobutyl-phthalate.html HYPERLINK https:/www.MedChemE/butyl-isobutyl-phthalate.html phthalateCat. No.: HY-N4095 Cat. No.: HY-N7377Brevifolincarboxylic acid

29、is extracted fromPolygonum capitatum, has inhibitory effecton the aryl hydrocarbon receptor (AhR).Brevifolincarboxylic acid is an -glucosidaseinhibitor with an IC of 323.46 M.50Butyl isobutyl phthalate is isolated from therhizoid of Laminaria japonica. Butyl isobutylphthalate is a non-competitive -g

30、lucosidaseinhibitor with an IC value of 38 M. Butyl50isobutyl phthalate shows a hypoglycemic effect andhas the potential for diabetes treatment.Purity: 99.80%Clinical Data: No Development ReportedSize: 5 mg, 10 mgPurity: 98.77%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 50 mg, 100 mg HYP

31、ERLINK https:/www.MedChemE/Castanospermine.html Castanospermine HYPERLINK https:/www.MedChemE/Castanospermine.html HYPERLINK https:/www.MedChemE/cedryl-acetate.html Cedryl HYPERLINK https:/www.MedChemE/cedryl-acetate.html HYPERLINK https:/www.MedChemE/cedryl-acetate.html acetateCat. No.: HY-N2022 Ca

32、t. No.: HY-W009417Castanospermine inhibits all forms of - and-glucosidases, especially glucosidase l (requiredfor glucoprotein processing by transfer of mannoseand glucose from asparagine-linked lipids).target- and -glucosidases.Cedryl acetate is a tricyclic sesquiterpeneisolated from the plant Psid

33、ium caudatum.Cedryl acetate shows -glucosidase inhibitoryactivity.Purity: 98.0%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 10 mg, 50 mg, 100 mgPurity: 98.0%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 100 mg HYPERLINK https:/www.MedChemE/Cefetrizole.html Cefetrizole HYPERLINK

34、https:/www.MedChemE/Cefetrizole.html HYPERLINK https:/www.MedChemE/Celgosivir.html CelgosivirCat. No.: HY-U00266(MBI 3253; MDL 28574; MX3253) Cat. No.: HY-16134Ceftezole is an -Glucosidase inhibitor with anIC50 and a Ki of 2.1 M and 0.578 M,respectively.Celgosivir (MBI 3253; MDL 28574; MX3253) is an

35、-glucosidase I inhibitor; inhibits bovine viraldiarrhoea virus (BVDV) with an IC of 1.27 M in50in vitro assay.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98%Clinical Data: Phase 2Size: 5 mg, 10 mg, 25 mgwww.MedChemE 3 HYPERLINK https:/www.MedChemE/Celgosivir-hydrochlorid

36、e.html Celgosivir HYPERLINK https:/www.MedChemE/Celgosivir-hydrochloride.html HYPERLINK https:/www.MedChemE/Celgosivir-hydrochloride.html hydrochloride HYPERLINK https:/www.MedChemE/Celgosivir-hydrochloride.html (MBI 3253 hydrochloride; MDL 28574hydrochloride; MX3253 hydrochloride) Cat. No.: HY-1613

37、4A HYPERLINK https:/www.MedChemE/chrysophanol-triglucoside.html Chrysophanol HYPERLINK https:/www.MedChemE/chrysophanol-triglucoside.html HYPERLINK https:/www.MedChemE/chrysophanol-triglucoside.html triglucosideCat. No.: HY-N7599Celgosivir hydrochloride (MBI 3253 hydrochloride;MDL 28574 hydrochlorid

38、e; MX3253 hydrochloride) isan -glucosidase I inhibitor; inhibits bovine viraldiarrhoea virus (BVDV) with an IC of 1.27 M in50in vitro assay.Chrysophanol triglucoside is an anthraquinoneisolated from Cassia obtusifolia, inhibits proteintyrosine phosphatases 1B (PTP1B) and -glucosidasewith IC s of 80.

39、17 and 197.06 M, respectively.50Chrysophanol triglucoside has the potential fordiabetes research.Purity: 98.0%Clinical Data: Phase 2Size: 10 mM 1 mL, 1 mg, 5 mg, 10 mg, 25 mg, 50 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg HYPERLINK https:/www.MedChemE/Conduritol-B-epoxide.html Con

40、duritol HYPERLINK https:/www.MedChemE/Conduritol-B-epoxide.html HYPERLINK https:/www.MedChemE/Conduritol-B-epoxide.html B HYPERLINK https:/www.MedChemE/Conduritol-B-epoxide.html HYPERLINK https:/www.MedChemE/Conduritol-B-epoxide.html epoxide HYPERLINK https:/www.MedChemE/Conduritol-B-epoxide.html HY

41、PERLINK https:/www.MedChemE/eb-0150.html EB-0150Cat. No.: HY-100944 Cat. No.: HY-145273Conduritol B epoxide is an irreversible covalentlybound acid -glucosidase (GCase) inhibitor.EB-0150 is a potent inhibitor of ER-glucosidases (-Glu) Iand II with IC s of 0.7350and 0.0337 M, respectively. EB-0150 is

42、 aN-substituted derivative of valiolamine withbroad-spectrum antiviral.Purity: 98.0%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/eb-0156.html EB-0156 HYPERLINK

43、https:/www.MedChemE/eb-0156.html HYPERLINK https:/www.MedChemE/eb-0176.html EB-0176Cat. No.: HY-145274 Cat. No.: HY-145275EB-0156 is a potent inhibitor of ER-glucosidases (-Glu) Iand II with IC s of 0.047950and less than 0.001 M, respectively. EB-0156 is aN-substituted derivative of valiolamine with

44、broad-spectrum antiviral.EB-0176 is a potent inhibitor of ER-glucosidases (-Glu) Iand II with IC s of 0.643950and 0.0011 M, respectively. EB-0176 is aN-substituted derivative of valiolamine withbroad-spectrum antiviral.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98%Clini

45、cal Data: No Development ReportedSize: 5 mg, 10 mg, 50 mg, 100 mg HYPERLINK https:/www.MedChemE/eleutherol.html Eleutherol HYPERLINK https:/www.MedChemE/eleutherol.html HYPERLINK https:/www.MedChemE/fucoidan.html FucoidanCat. No.: HY-N7626 Cat. No.: HY-132179Eleutherol is a naphthalene isolated from

46、 E.americana with antifungal activities. Eleutherolis against yeasts Candida albicans, C. tropicalis,Saccharomyces cerevisiae and Cryptococcusneoformans with MIC values between 7.8 g/mLand 250 g/mL.Fucoidan, a biologically active polysaccharide, isan efficient inhibitor of -amylase and-glucosidase.

47、Anticoagulant, antitumor,antioxidant and antisteatotic activities.Purity: 98%Clinical Data: No Development ReportedSize: 1 mgPurity: 98.0%Clinical Data: No Development ReportedSize: 100 mg, 250 mg, 500 mg HYPERLINK https:/www.MedChemE/ganoderic-acid-y.html Ganoderic HYPERLINK https:/www.MedChemE/gan

48、oderic-acid-y.html HYPERLINK https:/www.MedChemE/ganoderic-acid-y.html acid HYPERLINK https:/www.MedChemE/ganoderic-acid-y.html HYPERLINK https:/www.MedChemE/ganoderic-acid-y.html Y HYPERLINK https:/www.MedChemE/ganoderic-acid-y.html HYPERLINK https:/www.MedChemE/ganoderlactone-d.html Ganoderlactone

49、 HYPERLINK https:/www.MedChemE/ganoderlactone-d.html HYPERLINK https:/www.MedChemE/ganoderlactone-d.html DCat. No.: HY-125713 Cat. No.: HY-N3503Ganoderic acid Y is a -glucosidase inhibitor withan IC of 170 M for yeast -glucosidase.50Ganoderic acid Y inhibits enterovirus 71 (EV71)replication through

50、blocking EV71 uncoating.Ganoderlactone D shows inhibitory effects of yeast-Glucosidase with IC values of 41.7 M.50Purity: 99.07%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 99.0%Clinical Data: No Development ReportedSize: 1 mg, 5 mg4 Tel: 609-228-6898 Fax: 609-228-5909 Email: salesM

51、edChemE HYPERLINK https:/www.MedChemE/ganoderol-b.html Ganoderol HYPERLINK https:/www.MedChemE/ganoderol-b.html HYPERLINK https:/www.MedChemE/ganoderol-b.html B(Ganodermadiol) Cat. No.: HY-N2223 HYPERLINK https:/www.MedChemE/LTI-291.html Gcase HYPERLINK https:/www.MedChemE/LTI-291.html HYPERLINK htt

52、ps:/www.MedChemE/LTI-291.html activator HYPERLINK https:/www.MedChemE/LTI-291.html HYPERLINK https:/www.MedChemE/LTI-291.html 1Cat. No.: HY-104038Ganoderol B is a potent -glucosidase inhibitor.Ganoderol B has high -glucosidase inhibition withan IC of 48.5 g/mL (119.8 M).50Gcase activator 1 is an act

53、ivator ofglucocerebrosidase (Gcase) extracted from patentWO 2017192841 A1.Purity: 98%Clinical Data: No Development ReportedSize: 5 mg, 10 mg, 25 mgPurity: 98.77%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg HYPERLINK https:/www.MedChemE/gitogenin.html Gito

54、genin HYPERLINK https:/www.MedChemE/gitogenin.html HYPERLINK https:/www.MedChemE/glycyrrhisoflavone.html GlycyrrhisoflavoneCat. No.: HY-N2574 Cat. No.: HY-N3962Gitogenin is a natural steroid isolated from thewhole plant of Tribulus longipetalus.Glycyrrhisoflavone, an active prenylflavonoid,inhibits

55、-glucosidase.Purity: 99.82%Clinical Data: No Development ReportedSize: 5 mg, 10 mg, 20 mgPurity: 98%Clinical Data: No Development ReportedSize: 5 mg, 10 mg, 25 mg HYPERLINK https:/www.MedChemE/Hexylresorcinol.html Hexylresorcinol(4-Hexylresorcinol) Cat. No.: HY-B0986 HYPERLINK https:/www.MedChemE/ih

56、vr-17028.html IHVR-17028Cat. No.: HY-139663Hexylresorcinol (4-Hexylresorcinol) is a naturalcompound found in plants with antimicrobial,anthelmintic, antiseptic and antitumor activities.Hexylresorcinol can induce apoptosis in squamouscarcinoma cells.Purity: 98.29%Clinical Data: LaunchedSize: 10 mM 1

57、mL, 500 mg, 1 gIHVR-17028 is a potent and broad-spectrum antiviralagent. IHVR-17028 exhibits antiviral activityagainst BVDV, TCRV and DENV with EC values of500.4 M, 0.26 M, 0.3 M, respectively. IHVR-17028is a potent ER -glucosidase I inhibitorwith an IC of 0.24 M.50Purity: 98%Clinical Data: No Devel

58、opment ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/ihvr-19029.html IHVR-19029 HYPERLINK https:/www.MedChemE/ihvr-19029.html HYPERLINK https:/www.MedChemE/Isotanshinone_I.html Isotanshinone HYPERLINK https:/www.MedChemE/Isotanshinone_I.html HYPERLINK https:/www.MedChemE/Isotanshinone_I.htm

59、l ICat. No.: HY-124662 Cat. No.: HY-N6649IHVR-19029 is a potent endoplasmic reticulum (ER)-glucosidases I and II inhibitor, with an IC of500.48 M for ER a-glucosidase I.Isotanshinone I has inhibitory activity against-glucosidase and formation of AGE, with IC s of501.13 M and 0.432 M for -glucosidase

60、 and AGE,respectively.Purity: 96.0%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 5 mg, 10 mg, 50 mg, 100 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/kaempferol-3-o-gentiobioside.html Kaempferol HYPERLINK https:/www.MedChemE/kaempferol-3