馬來酸依那普利作用機(jī)制 - Medchemexpress - MCE中國

1、Product Data SheetEnalapril maleateCat. No.: HY-B0331ACAS No.: 76095-16-4分式: CHNO分量: 492.52作靶點(diǎn): Angiotensin-converting Enzyme (ACE)作通路: Metabolic Enzyme/Protease儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 50 mg/mL (101.52 mM)H2O : 33.33 mg/mL (67.67 mM; Nee

2、d ultrasonic and warming)* means soluble, but saturation unknown.SolventMass1 mg 5 mg 10 mgConcentration制備儲(chǔ)備液1 mM 2.0304 mL 10.1519 mL 20.3037 mL5 mM 0.4061 mL 2.0304 mL 4.0607 mL10 mM 0.2030 mL 1.0152 mL 2.0304 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲(chǔ)備液的保存式和期限：-80C, 6 months; -20C,

3、 1 month。-80C 儲(chǔ)存時(shí)，請?jiān)?6 個(gè)內(nèi)使，-20C 儲(chǔ)存時(shí)，請?jiān)?1 個(gè)內(nèi)使。BIOLOGICAL ACTIVITY物活性 Enalapril maleate (MK-421 maleate)Enalapril 的活性代謝物， 管緊張素轉(zhuǎn)化酶（ACE）抑制劑。IC & Target ACE1.體內(nèi)研究 Enalapril (MK-421) is a prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class ofmedications. It is rapidly metaboliz

4、ed in the liver to enalaprilat following oral administration. Enalapril (MK-421) is a potent, competitive inhibitor of ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensinII (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldoster

5、one system (RAAS).Enalapril may be used to treat essential or renovascular hypertension and symptomatic congestive heart failure1.Page 1 of 2 www.MedChemE戶使本產(chǎn)品發(fā)表的科研獻(xiàn) Environ Pollut. 2019 Apr;247:927-934. Toxicol Lett. 2019 Jul;309:42-50.See more customer validations on HYPERLINK www.MedChemE www.Med

6、ChemEREFERENCES1. Liu, Y.H., et al., Comparison of captopril and enalapril to study the role of the sulfhydryl-group in improvement of endothelial dysfunction with ACEinhibitors in high dieted methionine mice. J Cardiovasc Pharmacol, 2006. 47(1): p. 82-8.McePdfHeightCaution: Product has not been fully validated for medical applications. For research use only.Tel: 400-820-3792; 021-58955