氯前列烯醇納作用機制 - Medchemexpress - MCE中國

1、Product Data SheetCloprostenol sodium saltCat. No.: HY-108415CAS No.: 55028-72-3分式: CHClNaO分量: 446.9作靶點: Prostaglandin Receptor作通路: GPCR/G Protein儲存式: 4C, sealed storage, away from moisture* In solvent : -80C, 6 months; -20C, 1 month (sealed storage, away frommoisture)溶解性數(shù)據(jù)體外實驗 H2O : 150 mg/mL (335.

2、65 mM)* means soluble, but saturation unknown.SolventMass1 mg 5 mg 10 mgConcentration制備儲備液1 mM 2.2376 mL 11.1882 mL 22.3764 mL5 mM 0.4475 mL 2.2376 mL 4.4753 mL10 mM 0.2238 mL 1.1188 mL 2.2376 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲備液的保存式和期限：-80C, 6 months; -20C, 1 month (sealed st

3、orage, away from moisture)。-80C 儲存時，請在 6 個內(nèi)使，-20C 儲存時，請在 1 個內(nèi)使。BIOLOGICAL ACTIVITY物活性 Cloprostenol sodium salt (ICI 80996 sodium salt) PGF2 receptor 的激動劑2。種合成的、有效的前列腺素類似物，具有黃體溶解性1，為IC & Target PGF2 receptor2體外研究 Cloprostenol is a PGF2 receptor agonist2.Cloprostenol (0.1 M) counteracts the adipogenic

4、 effects of statil, on both intracellular lipid accumulation andexpression of transcripts for proadipogenic factors C/EBP and PPAR after treatment for 6 days2.體內(nèi)研究 Cloprostenol sodium salt (25 g) decreases plasma progesterone in pregnant rats1.Page 1 of 2 www.MedChemEREFERENCES1. Salazar H, et al. L

5、uteolytic effects of a prostaglandin analogue, cloprostenol (ICI 80,996), in rats: ultrastructural and biochemical observations. BiolReprod. 1976 May;14(4):458-72.2. Pastel E, et al. Aldose reductases influence prostaglandin F2 levels and adipocyte differentiation in male mouse and human species. Endocrinology.2015 May;156(5):1671-84.McePdfHeightCaution: Product has not been fully validated for medical applications. For research use only.Tel: 400-820-3792;Fax: 02