CBR-5884-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemECBR-5884Cat. No.: HY-100012CAS No.: 681159-27-3分式: CHNOS分量: 336.39作靶點: Others作通路: Others儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 DMSO : 50 mg/mL (148.64 mM; Need ultrasonic)H2O : 40% PEG300

2、 5% Tween-80 45% salineSolubility: 2.08 mg/mL (6.18 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.08 mg/mL (6.18 mM); Clear solution1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEBIOLOGICAL ACTIVITY物活性 CBR-5884種有效，選擇性的磷酸油酸脫氫酶 (PHGDH) 抑制劑，IC50 為 33 M。 CBR-5884 抑制癌細(xì)胞中的絲氨酸合成，并且對

3、具有絲氨酸物合成活性的癌細(xì)胞系具有選擇性毒性。 CBR-5884 選擇性地抑制素瘤和乳腺癌細(xì)胞系的增殖。IC50 & Target PHGDH, serine synthesis 1體外研究 CBR-5884 (15 or 30 M; 3-5 days) selectively inhibits the proliferation of melanoma and breast cancer linesthat have a high propensity for serine synthesis.Cell Proliferation Assay 1Cell Line: Breast and m

4、elanoma cell linesConcentration: 15 or 30 MIncubation Time: 3-5 daysResult: Inhibited the proliferation of melanoma and breast cancer lines.戶使本產(chǎn)品發(fā)表的科研獻(xiàn) Nat Commun. 2019 Jun 20;10(1):2701.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Edouard Mullarky et al. Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis incancersProc Natl Acad Sci U S A, 2016 Feb 16, 113(7):1778-83.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-589559