Yohimbine-Hydrochloride _Adrenergic Receptor Antagonist - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEYohimbine HydrochlorideCat. No.: HY-N0127CAS No.: 65-19-0分式: CHClNO分量: 390.9作靶點: Adrenergic Receptor作通路: GPCR/G Protein; Neuronal Signaling儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 DMSO : 33

2、.33 mg/mL (85.26 mM; Need ultrasonic)H2O : 4 mg/mL (10.23 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 2.5582 mL 12.7910 mL 25.5820 mL5 mM 0.5116 mL 2.5582 mL 5.1164 mL10 mM 0.2558 mL 1.2791 mL 2.5582 mL請根據(jù)產品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內實驗請根據(jù)您的實驗動物和給藥式選擇適當?shù)娜芙獍?，?/p>

3、制前請先配制澄清的儲備液，再依次添加助溶劑(為保證實驗結果的可靠性，體內實驗的作液，建議您現(xiàn)現(xiàn)配，當天使；澄清的儲備液可以根據(jù)儲存條件，適當保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (6.40 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (6.40 mM); Clear solution3

4、. 請依序添加每種溶劑： 10% DMSO 90% corn oil1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemESolubility: 2.5 mg/mL (6.40 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Yohimbine Hydrochloride是-2腎上腺素能受體抑制劑，阻斷突觸前或突觸后的 -2腎上腺素能受體，引起去甲腎上腺素和多巴胺的釋放。體內研究 Yohimbine Hydrochloride (0.2 mg/kg, i.p.) was administered to rats 1

5、h before the stress session daily for 14consecutive days and its effect was assessed. Results of this section revealed that, immersion of rats in coldwater significantly decreased sexual arousal and motivation as indicated by increased latencies andintervals. Decreased copulatory activity was confir

6、med by decreased testosterone, luteinizing hormone (LH)and follicle-stimulating-hormone (FSH) levels as well as decreased cholesterol content in rat testes.Treatment with yohimbine significantly increased the sexual arousal and potency and corrected the effectsinduced by stress on the mating behavio

7、r of male rats 1.REFERENCES1. Saad MA, et al. Potential effects of yohimbine and sildenafil on erectile dysfunction in rats.2. Docherty JR. Yohimbine antagonises 1A- and 1D-adrenoceptor mediated components in addition to the 2A-adrenoceptorcomponent to pressor responses in the pithed rat. Eur J Phar

8、macol. 2012 Mar 15;679(1-3):90-4.3. Lahiri P, et al. Platelet responsiveness to yohimbine hydrochloride and MRS2179 in the context of the interaction between collagen andepinephrine in acute coronary syndrome. Blood Cells Mol Dis. 2009 Jul-Aug;43(1):105-10.McePdfHeightCaution: Product has not been fully validated for medical applications.F