MGCD-265-analog-DataSheet-生命科學試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEMGCD-265 analogCat. No.: HY-10991CAS No.: 875337-44-3分式: CHFNOS分量: 517.6作靶點: c-Met/HGFR; VEGFR作通路: Protein Tyrosine Kinase/RTK儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 DMSO : 100 mg/mL (193.

2、20 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 1.9320 mL 9.6600 mL 19.3199 mL5 mM 0.3864 mL 1.9320 mL 3.8640 mL10 mM 0.1932 mL 0.9660 mL 1.9320 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內(nèi)實驗請根據(jù)您的實驗動物和給藥式選擇適當?shù)娜芙獍?，配制前請先配制澄清的儲備液，再依次添加助溶?為保證實驗結(jié)果的可靠性

3、，體內(nèi)實驗的作液，建議您現(xiàn)現(xiàn)配，當天使；澄清的儲備液可以根據(jù)儲存條件，適當保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.75 mg/mL (5.31 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.75 mg/mL (5.31 mM); Clear solution3. 請依序添加每種溶劑： 10% DMSO 90% corn

4、oil1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemESolubility: 2.75 mg/mL (5.31 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 MGCD265-analog結(jié)構(gòu)上與MGCD-265相似, MGCD265-analog種有效的多靶點酪氨酸激酶抑制劑,作于c-Met, VEGFR2， IC50值分別為29 nM和10 nM。IC50 & Target VEGFR2 c-Met10 nM (IC50) 29 nM (IC50)戶使本產(chǎn)品發(fā)表的科研獻 Harvard Medical S

5、chool LINCS LIBRARYSee more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Claridge S, et al. Discovery of a novel and potent series of thieno3,2-bpyridine-based inhibitors of c-Met and VEGFR2 tyrosine kinases.Bioorg Med Chem Lett. 2008 May 1;18(9):2793-8.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-