Nanchangmycin-Nanchangmycin-A-DataSheet-生命科學試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemENanchangmycinCat. No.: HY-100528CAS No.: 65101-87-3Synonyms: Nanchangmycin A分式: CHNaO分量: 889.1作靶點: Bacterial作通路: Anti-infection儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 DMSO : 30 mg/mL (33.7

2、4 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 1.1247 mL 5.6237 mL 11.2473 mL5 mM 0.2249 mL 1.1247 mL 2.2495 mL10 mM 0.1125 mL 0.5624 mL 1.1247 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內(nèi)實驗 請根據(jù)您的實驗動物和給藥式選擇適當?shù)娜芙獍?，配制前請先配制澄清的儲備液，再依次添加助溶?為保證實驗結(jié)果的可靠性

3、，體內(nèi)實驗的作液，建議您現(xiàn)現(xiàn)配，當天使；澄清的儲備液可以根據(jù)儲存條件，適當保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (2.81 mM); Suspended solution; Need ultrasonic2. 請依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (2.81 mM); Clear solution1/2 Master of Small Molecul

4、es 您邊的抑制劑師www.MedChemEBIOLOGICAL ACTIVITY物活性 Nanchangmycin 由 Streptomyces nanchangensis NS3226 產(chǎn)的，抑制蘭陽性菌。Nanchangmycin 也種抗 Zika 病毒的譜抗病毒藥物。IC50 & Target Bacteria 1Zika virus 2體外研究 Nanchangmycin can be used as a growth promotant in poultry and to cure coccidiosis in chickens.Nanchangmycin is active ag

5、ainst drug resistant strains of malaria 1. Nanchangmycin as a potent inhibitor ofZika virus (ZIKV) entry across all cell types tested including physiologically relevant primary cells.Nanchangmycin potently reduces infection of all three strains of ZIKV across all three cell types. The IC50sfor infec

6、tion are between 0.1 and 0.4 M while Nanchangmycin has low toxicity in these ranges. In addition,DENV is inhibited by Nanchangmycin across cell types 2.REFERENCES1. Liu T et al. Mechanism of thioesterase-catalyzed chain release in the biosynthesis of the polyether antibiotic nanchangmycin. Chem Biol.2008 May;15(5):449-58.2. Rausch K, et al. Screening Bioactives Reveals Nanchangmycin as a Broad Spectrum Antiviral Active against Zika Virus. Cell Rep. 2017Jan 17;18(3):804-815.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use onl