HDAC8-IN-1 - HDAC 抑制劑 - 生命科學(xué)試劑 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEHDAC8-IN-1Cat. No.: HY-111342CAS No.: 1417997-93-3分式: CHNO分量: 345.39作靶點(diǎn): HDAC作通路: Cell Cycle/DNA Damage; Epigenetics儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 150 mg/mL (434.29 mM; Nee

2、d ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 2.8953 mL 14.4764 mL 28.9528 mL5 mM 0.5791 mL 2.8953 mL 5.7906 mL10 mM 0.2895 mL 1.4476 mL 2.8953 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 HDAC8-IN-1個(gè) HDAC8 抑制劑，其 IC50 值為 27.2 nM。IC50 & Target HDAC827.2 nM (I

3、C50)體外研究HDAC8-IN-1 is a HDAC8 inhibitor with an IC50 of 27.2 nM in cancer cell lines. HDAC8-IN-1 (compound 22 d)shows antiproliferative effects toward several human lung cancer cell lines (A549, H1299, and CL1-5);1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEHDAC8-IN-1 exhibits cytotoxicity again

4、st human lung CL1-5 cells without significant cytotoxicity for normalIMR-90 cells 1.REFERENCES1. Huang WJ, et al. Synthesis and biological evaluation of ortho-aryl N-hydroxycinnamides as potent histone deacetylase (HDAC) 8isoform-selective inhibitors. ChemMedChem. 2012 Oct;7(10):1815-24.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fax: