RS-AMPA-monohydrate-racemic-AMPA-monohydrate-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemE(RS)-AMPAmonohydrateCat.No.:HY-100815DCASNo.:76463-67-7Synonyms:(±)-AMPAmonohydrate分?式:C?H??N?O?分?量:204.18作?靶點(diǎn):iGluR作?通路:MembraneTransporter/IonChannel;NeuronalSignaling儲(chǔ)存?式:-20°C,protectfromlight,storedundernitrogen*Insolvent:-80°C,6months;-20°C,1month(protectfrom

light,storedundernitrogen)溶解性數(shù)據(jù)體外實(shí)驗(yàn)H2O:5mg/mL(24.49mM;ultrasonicandwarmingandheatto60°C)MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM4.8976mL24.4882mL48.9764mL5mM0.9795mL4.8976mL9.7953mL10mM0.4898mL2.4488mL4.8976mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；?旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲(chǔ)備液的保存?式和期限：-80°C,6months;-20°C,1month(protectfromlight,storedundernitrogen)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?。BIOLOGICALACTIVITY?物活性(RS)-AMPA((±)-AMPA)monohydrate?種?氨酸類似物，?種有效的選擇性興奮性神經(jīng)遞質(zhì)L-?氨酸(L-glutamicacid)激動(dòng)劑。(RS)-AMPAmonohydrate不會(huì)?擾海藻酸或NMDA受體的結(jié)合位點(diǎn)。體外研究(RS)-AMPAmonohydrate(10-3-10-4M)causesdepolarizationsofculturedratspinalandbrainstemneurones.Thedepolarizationby(RS)-AMPAmonohydrateisclearlydose-dependent,althoughthereisa1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEgreatvariabilityofeffectsbetweenindividualneurones.Applicationof(RS)-AMPAmonohydrateat10-5Mproducesonlysmalldepolarizations(3-7mV),whereasat10-4M,theamplitudesofthedepolarizationsrangedfrom4to33mV.(RS)-AMPAmonohydratealsocausesanincreaseofthedischargerateofspontaneouslyfiringneuronesorsometimesevokedashortburstofactionpotentialsinsilentcells.(RS)-AMPAmonohydrateexertsitsdepolarizingeffectsbyactivatingglutamate/quisqualatereceptorswithoutaffectingNMDAreceptors[1].REFERENCES[1].H?sliL,etal.EffectsoftheglutamateanalogueAMPAanditsinteractionwithantagonistsonculturedratspinalandbrainstemneurones.NeurosciLett.1983Mar28;36(1):59-62.[2].SommerB,etal.Flipandflop:acell-specificfunctionalswitchinglutamate-operatedchannelsoftheCNS.Science.1990Sep28;249(4976):1580-5.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.