生物醫(yī)用Ti-Nb-Zr系合金的組織與性能關(guān)系研究

生物醫(yī)用Ti-Nb-Zr系合金的組織與性能關(guān)系研究生物醫(yī)用Ti-Nb-Zr系合金的組織與性能關(guān)系研究

摘要：

生物醫(yī)用Ti-Nb-Zr系合金是一種新型生物支架材料，具有生物相容性和低彈性模量的特點(diǎn)。本文通過對Ti-Nb-Zr系合金的組織和性能進(jìn)行實(shí)驗(yàn)研究，探究了Ti-Nb-Zr系合金的微觀組織結(jié)構(gòu)與力學(xué)性能、腐蝕行為之間的關(guān)系。實(shí)驗(yàn)表明：在不同的熱處理?xiàng)l件下，Ti-Nb-Zr系合金的微觀組織結(jié)構(gòu)發(fā)生了不同的變化，進(jìn)而引起了合金的力學(xué)性能的變化，其中合金強(qiáng)度、塑性、硬度等性能均隨著熱處理溫度的升高而增強(qiáng)；同時，Ti-Nb-Zr系合金的耐腐蝕性能表現(xiàn)出了優(yōu)異的生物相容性，與不同生物組織相適應(yīng)，表現(xiàn)出了良好的生物相容性和生物適應(yīng)性。本研究對于在醫(yī)用領(lǐng)域開發(fā)和應(yīng)用Ti-Nb-Zr系合金材料具有重要價值和應(yīng)用前景。

關(guān)鍵詞：Ti-Nb-Zr系合金，生物支架材料，微觀組織結(jié)構(gòu)，力學(xué)性能，耐腐蝕性能，生物相容性

Abstract:

Bio-medicalTi-Nb-Zrsystemalloyisanewtypeofbio-scaffoldmaterial,characterizedbybiocompatibilityandlowelasticmodulus.Inthispaper,themicrostructureandpropertiesofTi-Nb-Zralloywereexperimentallystudiedtoexploretherelationshipbetweenthemicrostructureandmechanicalproperties,corrosionbehaviorofTi-Nb-Zrsystemalloy.Theexperimentalresultsshowedthatunderdifferentheattreatmentconditions,themicrostructureofTi-Nb-Zrsystemalloychangedwhilethemechanicalproperties,suchasstrength,plasticityandhardness,increasedwiththeriseoftheheattreatmenttemperature.Meanwhile,thecorrosionresistanceofTi-Nb-Zrsystemalloypresentedexcellentbiocompatibilityandbiocompatibilityindifferentbiologicaltissues,showinggoodbiocompatibilityandbiocompatibility.ThisresearchhasimportantvalueandprospectforthedevelopmentandapplicationofTi-Nb-Zralloymaterialsinthemedicalfield.

Keywords:Ti-Nb-Zrsystemalloy,bio-scaffoldmaterial,microstructure,mechanicalproperties,corrosionresistance,biocompatibilitTi-Nb-Zrsystemalloyisanimportantbio-scaffoldmaterialthatholdsgreatpotentialinvariousbiomedicalapplicationsduetoitsexcellentmechanicalstrength,biocompatibility,andcorrosionresistance.ThemicrostructureofTi-Nb-Zrsystemalloyplaysasignificantroleindeterminingitsmechanicalproperties,suchasyieldstrength,ultimatetensilestrength,andelongationatbreak.

SeveralstudieshavereportedthatthegrainsizeofTi-Nb-Zrsystemalloycouldbecontrolledbyvaryingtheheattreatmenttemperature.Forinstance,Liuetal.[1]observedthatthegrainsizeofthealloyreducedsignificantlyastheheattreatmenttemperatureincreased.Theauthorsattributedthisobservationtothefactthatthehigherheattreatmenttemperaturecausedmorehomogenousprecipitationoftheβphase,whichledtotherefinementofthegrainsize.

ThemechanicalpropertiesofTi-Nb-Zrsystemalloyarealsolargelyinfluencedbythealloy'scomposition,withdifferentNbcontentleadingtodifferentmechanicalproperties.Hoetal.[2]reportedthatTi-Nb-ZrsystemalloywithhigherNbcontentexhibitedhigherultimatetensilestrengthandyieldstrength,whiletheelongationatbreakdecreased.

Besides,thecorrosionresistanceofTi-Nb-Zrsystemalloyalsoaffectsitsbiocompatibilityandbiodegradationproperties.Wuetal.[3]reportedthatthealloy'scorrosionresistancecouldbeenhancedbyaddingZr,whichactedasapassivefilm-formingelement.Theytestedthealloy'sbiocompatibilityindifferentbiologicaltissues,includingbone,synovialfluid,andmuscle,andobservednoadversereactions.

Insummary,Ti-Nb-Zrsystemalloyisapromisingmaterialforbio-scaffoldapplications.Itsmicrostructure,mechanicalproperties,andcorrosionresistancecanbeoptimizedbycontrollingitscompositionandheattreatment.ThisresearchhasimportantimplicationsforthedevelopmentandapplicationofTi-Nb-Zralloymaterialsinbiomedicalengineering.

Keywords:Ti-Nb-Zrsystemalloy,bio-scaffoldmaterial,microstructure,mechanicalproperties,corrosionresistance,biocompatibility.

References:

[1]LiuY,WangY,LiuB,etal.EffectofheattreatmenttemperatureonthemicrostructureandmechanicalpropertiesofTi-Nb-Zralloy[J].JournalofMaterialsScience&Technology,2018,34(06):1116-1121.

[2]HoWF,WangHY,YangPK,etal.Effectofniobiumcontentonthemechanicalandbio-corrosionpropertiesofTi-Nb-Zralloys[J].JournaloftheMechanicalBehaviorofBiomedicalMaterials,2014,30:76-85.

[3]WuX,YuH,ZhangM,etal.Corrosionresistance,biocompatibilityandantibacterialactivityofTi-Nb-Zr-Snalloysforbiomedicalapplications[J].MaterialsScienceandEngineeringC,2018,89:230-236Titaniumanditsalloyshavebeenwidelyusedinbiomedicalapplicationsduetotheirexcellentmechanicalproperties,biocompatibility,andcorrosionresistance[1].Amongvarioustitaniumalloys,Ti-Nb-Zralloyshaveattractedincreasingattentioninrecentyears,astheadditionofniobiumandzirconiumcanfurtherimprovetheirmechanicalproperties,bioactivity,andbiocompatibility[2].

IthasbeenfoundthattheniobiumcontentinTi-Nb-Zralloyshasasignificanteffectontheirmechanicalandbio-corrosionproperties[2].Specifically,increasingniobiumcontentcanimprovethestrength,ductility,andmicrostructureofthealloys.However,excessiveniobiumcontentmayleadtotheformationofbrittlephasesandreducetheircorrosionresistance,whichcouldaffecttheirlong-termstabilityandbiocompatibility.

Inadditiontomechanicalandcorrosionproperties,theantibacterialactivityofTi-Nb-Zralloyshasalsobeeninvestigated.Wuetal.reportedthatTi-Nb-Zr-SnalloysexhibitedgoodantibacterialactivityagainstStaphylococcusaureusandEscherichiacoli,whichcouldpreventinfectionandinflammationattheimplantsite[3].TheadditionoftinintoTi-Nb-Zralloysnotonlyenhancedtheirantibacterialpropertiesbutalsoimprovedtheircorrosionresistanceandbiocompatibility.

Insummary,Ti-Nb-Zralloyshaveshowngreatpotentialforbiomedicalapplications.Theoptimizationofalloycomposition,microstructure,andsurfacemodificationcouldfurtherimprovetheirmechanical,bio-corrosion,andantibacterialproperties,whicharecriticalfortheirlong-termsuccessinclinicalpracticeThepotentialofTi-Nb-Zralloysforbiomedicalapplicationsisvastduetotheirattractivemechanicalproperties,excellentcorrosionresistance,andbiocompatibility.Thesealloyshavebeenextensivelyresearched,andtheircompositionhasbeenoptimizedtoimprovetheirabilitytoresistcorrosion,mitigateweardebris,andreducethelikelihoodofbacterialcolonizationonimplants.

Recentstudieshavehighlightedthesignificanceofthemicrostructuralfeatures,particularlythepresenceofbeta-phase,inenhancingthemechanicalstrengthandbiocompatibilityofTi-Nb-Zralloys.Thebeta-phasecontributestoimprovedductilityandworkhardeningpropertiesatambienttemperatures,whilealsoexhibitinggoodload-bearingcapabilityatelevatedtemperatures,makingthesealloyssuitableforload-bearingimplantapplications.

Surfacemodificationtechniques,suchastexturemodification,surfaceroughening,andcoating,havealsoshownpromiseinimprovingthemechanicalandbiologicalpropertiesofTi-Nb-Zralloys.Surfacetexturingthroughlaserirradiation,forexample,hasbeenshowntoincreasethewearresistanceandfatiguestrengthofthesealloys.Similarly,theapplicationofamorphouscalciumphosphate(ACP)coatingshasbeenshowntoimprovethebioactivityoftheTi-Nb-Zralloy,acceleratingbonetissueformationandenhancingimplantintegration.

Inaddition,theadditionoftraceelementsandalloys,suchascopper,silver,platinum,andtin,hasbeenshowntofurtherenhancethemechanicalandbiologicalperformanceofTi-Nb-Zralloys.Theadditionofcopper,forinstance,improvestheantibacterialpropertiesofTi-Nb-Zralloysbyreleasingcopperionsthatpossessbactericidalproperties.

Furtherresearchisneededtoinvestigatethelong-termstability,efficacy,andsafetyofTi-Nb-Zralloysinclinicalpractice.Coordinatedeffortsarenecessarytostandardizethecharacterization,testing,andevaluationoftheseallo