殼聚糖-石墨烯納米復(fù)合凝膠的制備及性能研究

殼聚糖-石墨烯納米復(fù)合凝膠的制備及性能研究摘要：本文通過將殼聚糖與石墨烯納米片層復(fù)合制備了一種新型的殼聚糖/石墨烯納米復(fù)合凝膠，并研究了其性能。通過掃描電子顯微鏡、透射電子顯微鏡、傅里葉變換紅外光譜儀等技術(shù)手段對其結(jié)構(gòu)與形貌進(jìn)行了表征。結(jié)果表明，殼聚糖/石墨烯納米復(fù)合凝膠的微觀形貌呈現(xiàn)出較高的結(jié)晶度和表面粗糙度，且具有良好的凝膠性能和可逆性。進(jìn)一步研究了其吸附性能和藥物控釋性能，表明該復(fù)合凝膠對某些離子和分子具有較好的吸附性能，并且在藥物控釋方面表現(xiàn)出優(yōu)異的性能，可以望其作為一種新型的生物醫(yī)用材料進(jìn)行進(jìn)一步研究和應(yīng)用。

關(guān)鍵詞：殼聚糖、石墨烯納米片層、復(fù)合凝膠、結(jié)構(gòu)表征、吸附性能、藥物控釋性能

Abstract:Inthispaper,anovelchitosan/graphenenanocompositegelwaspreparedbycombiningchitosanwithgraphenenanosheets,anditspropertieswereinvestigated.Thestructureandmorphologyofthegelwerecharacterizedbyscanningelectronmicroscopy,transmissionelectronmicroscopy,Fouriertransforminfraredspectrometer,etc.Theresultsshowedthatthemicrostructureofthechitosan/graphenenanocompositegelexhibitedhighcrystallinityandsurfaceroughness,andhadgoodgelpropertiesandreversibility.Theadsorptionanddrugreleasepropertiesofthegelwerefurtherstudied.Theresultsindicatedthatthecompositegelexhibitedexcellentadsorptionpropertiesforsomeionsandmolecules,andshowedsuperiordrugreleaseperformance.Itcanbeexpectedtobeanewtypeofbiomaterialforfurtherresearchandapplication.

Keywords:chitosan,graphenenanosheets,compositegel,structuralcharacterization,adsorptionproperties,drugreleasepropertiesChitosan-graphenenanosheetscompositegelwassuccessfullysynthesizedandcharacterizedintermsofitsstructuralandphysicalproperties.Thegelhadauniformstructure,andthegraphenenanosheetswerewell-dispersedwithinthechitosanmatrix.Thegelexhibitedgoodmechanicalpropertiesandhighswellingability,whichmadeitsuitableforvariousbiomedicalapplications.

Inaddition,theadsorptionpropertiesofthecompositegelwereinvestigated.Theresultsrevealedthatthegelhadexcellentadsorptioncapacityforcationicdyes,heavymetalions,andorganicpollutants.Thehighadsorptionefficiencywasattributedtothelargesurfaceareaofgraphenenanosheetsandtheabundanceofaminogroupsonthechitosanchain.

Furthermore,thedrugreleasepropertiesofthecompositegelwerealsoevaluated.Theresultsshowedthatthegelexhibitedasustainedreleasepatternforthemodeldrug,indicatingitspotentialfordrugdeliveryapplications.Thesustainedreleasebehaviorofthegelwasattributedtothereversibleinteractionsbetweenthedrugmoleculesandthefunctionalgroupsonthechitosanandgraphenenanosheets.

Tosumup,thechitosan-graphenenanosheetscompositegelexhibitedexcellentadsorptionanddrugreleaseproperties,makingitapromisingbiomaterialforvariousapplications,suchaswastewatertreatment,drugdelivery,andtissueengineering.FurtherresearchisneededtoexploreitsfullpotentialandoptimizeitspropertiesforspecificapplicationsInadditiontoitsexcellentadsorptionanddrugreleaseproperties,thechitosan-graphenenanosheetscompositegelhasseveralotheradvantagesthatmakeitapromisingbiomaterialforvariousapplications.Forinstance,bothchitosanandgraphenearebiocompatibleandbiodegradablematerials,whichminimizetherisksoftoxicityandadverseeffectswhenusedinvivo.Moreover,thecompositegelcanbeeasilysynthesizedusingsimpleandlow-costmethods,whichenhancesitsscalabilityandcost-effectivenessforlarge-scaleproductionandcommercialization.

Onepotentialapplicationofthechitosan-graphenenanosheetscompositegelisinwastewatertreatment,particularlyfortheremovalofheavymetalsandorganicpollutantsfromcontaminatedwatersources.Heavymetalssuchaslead,cadmium,andmercuryarehighlytoxicandbioaccumulative,posingsignificantenvironmentalandhealthriskswhendischargedintowaterbodies.Organicpollutants,includingpharmaceuticals,pesticides,andindustrialchemicals,arealsopersistentandpotentiallyhazardous,astheycanaffectaquaticorganismsandhumanhealththroughbioaccumulationandbiomagnification.Thecompositegel'shighadsorptioncapacityandselectivityforthesecontaminantsmakeitapromisingcandidateforwatertreatmentapplications,whereitcanbeusedasanadsorbentorfiltermaterialeitheraloneorincombinationwithothermaterials.

Anotherpotentialapplicationofthecompositegelisindrugdelivery,whereitcanbeusedasacarrierforvarioustherapeuticmolecules,includingsmallmolecules,peptides,proteins,andnucleicacids.Thecompositegel'shighdrugloadingcapacity,sustainedreleasekinetics,andabilitytotargetspecifictissuesorcellsmakeitanattractiveoptionforimprovingthesafetyandefficacyofdrugtherapies.Forinstance,thegelcouldbeusedtodeliveranticancerdrugsdirectlytotumorcellswhileminimizingsystemictoxicityandsideeffects.Additionally,thegel'stunableproperties,suchasitsporosity,stiffness,andsurfacechemistry,canbecustomizedforspecificdrugdeliveryapplications,enablingthedevelopmentofpersonalizedandoptimizedtherapies.

Finally,thechitosan-graphenenanosheetscompositegelcouldalsofindapplicationsintissueengineering,whereitcanbeusedasascaffoldormatrixforcellgrowthanddifferentiation.Thecompositegel'sbiocompatibility,biodegradability,andmechanicalstabilitymakeitanidealsubstrateforvarioustissueengineeringapproaches,suchascartilagerepair,boneregeneration,andwoundhealing.Moreover,thegel'ssurfacechemistryandelectricalconductivitycanbemodifiedtopromotecelladhesion,proliferation,anddifferentiation,enhancingtheintegrationofthescaffoldwiththesurroundingtissues.

Inconclusion,thechitosan-graphenenanosheetscompositegelisapromisingbiomaterialwithexcellentadsorptionanddrugreleaseproperties,aswellasotheradvantagessuchasbiocompatibility,biodegradability,andscalability.Itspotentialapplicationsincludewastewatertreatment,drugdelivery,andtissueengineering,amongothers.Furtherresearchisneededtooptimizethecompositegel'spropertiesandexploreitsfullpotentialinvariousapplicationsMoreover,thechitosan-graphenenanosheetscompositegelcanalsobepotentiallyusedinwoundhealingandregenerativemedicineduetoitsbiocompatibleandbiodegradablenature.Thegelcanactasascaffoldforcellgrowthandtissueregeneration,promotingthehealingprocess.Additionally,thecompositegelcanbemodifiedtoincorporategrowthfactorsandothertherapeuticagentstoenhancetissueregeneration.

Theexceptionaladsorptioncapabilityofthechitosan-graphenenanosheetscompositegelcanalsobeutilizedinwastewatertreatment.Thegelcanbeusedtoremoveheavymetalsandotherpollutantsfromwastewaterefficiently.Thechitosancomponentofthecompositegelhasapositivelychargedaminogroupthatcanattractandbindtonegativelychargedheavymetalsionsinthewastewater.Thegraphenenanosheets,ontheotherhand,providealargesurfaceareaforadsorptionduetotheiruniquetwo-dimensionalstructure.

Furthermore,thedrugdeliverypotentialofthechitosan-graphenenanosheetscompositegelcanbegreatlyutilizedinthefieldofcancertreatment.Thegelcanbeloadedwithchemotherapeuticagentsandusedintargeteddrugdeliverysystems.Thebiodegradableandbiocompatiblenatureofthecompositegelcanreducethetoxicityandadversesideeffectsofchemotherapeuticagentsonhealthycellswhileeffectivelytargetingcancercells.

Inconclusion,thechitosan-graphenenanosheetscompositegelisapromisingbiomaterialwith