第十二屆fmri培訓(xùn)課件talk12studies of cognition

MultimodalimagingMultimodalimagingstudiesofcognitionwithhealthyandpatientpopulationsYanchaoStateKeyLaboratoryofCognitiveNeuroscienceandLearningIDG/McernInstituteforBrainResearchBeijingNormalUniversity,includesattention,memory,producingandanddecisionmaking.3各3各種認(rèn)知過程是如何在大腦中實(shí)現(xiàn)的？哪些腦區(qū)負(fù)責(zé)加工、如何加工 腦手術(shù)如何避免認(rèn)知…語義-靜息態(tài)fMRI-健康被試(JN語義-DTI-腦損 (腦卒中、TBI等)(Brain視覺-結(jié)構(gòu)MRI-腦損傷(腦卒中、TBI等)(結(jié)合task;JN思路3taskfMRI:認(rèn)知任務(wù)與評估與taskfMRI反應(yīng)相視覺–taskfMRI–（JNSomeissuesandApproachApproachrelatedROI2.基于ROI的功 Koyamaetal.CerebralCortex,基于DosenbachetalNeuron2006fMRI實(shí)驗(yàn)激活的Peak點(diǎn)定義出執(zhí)行控制的ROI區(qū)域。建立每對ROIs之間的功能連接Dosenbachetal.,2007,分析分析二：Hierarchicalcluster分析分析一：設(shè)定r的閾Dosenbachetal.,2007,“任務(wù)執(zhí)行控制網(wǎng)絡(luò)來源UCSFMemoryandAgingCenterMAC數(shù)據(jù)庫Alzheimer’sdisease(AD,Behavioralvariantfrontotemporaldementia(bvFTD,n=24)Semanticdementia(SD,n=24)Progressivenonfluentaphasia(PNFA,n=13)Corticobasalsyndrome(CBS,n=17)控制組USCF17名正?？刂票籗eeleyetal.,2009,ttal.,2009,FC使用 在正常人上找出最大萎縮點(diǎn)做 全腦相似的ICN發(fā) 的萎縮模式和使用萎 找到的正常人s成分很一致PotentialHowcanwebesurethisisindeedrelatedtothatcognitivebehavior?——eachregionhasmanyApproachApproachCorrelatebrainmeasureswithcognitivebehavior 相關(guān)分析or - - - - -p05,t校正：clustersize>（反應(yīng)時(shí)…素兩兩組間不同的RSFC-閱讀成績相關(guān)關(guān)兩組間相同的RSFC-閱讀成績相關(guān)關(guān) Wigetal.(2008).MedialtemporallobeBOLDactivityatrestpredictsindividualdifferencesinmemoryabilityinhealthyyoungadults.PNAS.Wigetal，2008，ColeColeetal.2012TheJournalofAttentionDeficitsCarteretal.,2010,AnnalsofALFFand“A“Akindofanimal?Oftenseeninmyneighbourhood.Longnose, panymetogrocery Semanticimpairmentleadtodifficultiesinlanguage,objectrecognition,objectuse…Linetal.BranLang2010Bietal.Cortex2011Bietal.CogNeuropsych.CaseRussian tureprofessorinShanghai63yearold,lefttemporallobe34個(gè)健康右利手大學(xué)生被試（20人女性：22.5±1.3（20-26歲HowHowcanyoubesurethatthisissemantics,notothersorsomethingmuchmoregeneral?(meanWeietal.2012J.WhitematterWhitemattertractintegrityinpatientswithbraindamage WeietJ.34healthyResting-stateALFFinleftpMTGpredictssemanticprocessingAlsocheckedsemanticeffectcontrollingforcontrols“partialWordStroopShapeCuedConvergeConvergetotheregionsbysemantictasks(Binderetal.,2009,CC,meta-e.g.,Wirthetal.2011Semanticmemoryinvolvementinthedefaultmodenetworkafunctionalneuroimagingstudyusingindependent withdefaultmode腦腦損 (stroke,TBI,語義加工能Han,Ma,Gong,He,Caramazza,&Bi,2013,?Whitemattertractintegrityinpatientswithbraindamage76patientswithbrain51healthy-right--right--61-47years-27-13yearsofformal-50years-nopreviousbrain-13yearsofformal-atleast1monthpost--MSSE=-Abletofollowtask-MMSE=FLAIR:Fluidattenuatedinversionrecovery DiffusiontensorimagingRehabilitationResearchBeijingBoaiHospital Resting FLAIRFLAIR:Fluidattenuatedinversionrecovery DiffusiontensorimagingFLAIRStructureJHUWMtractography(Huaetal.,NeuroImage,Result1:TractsResult1:TractsrelatedtosemanticnNeural LV/ IndividualPatient2345lesionvolume:thenumber6voxelswithlesiondividedby7numberofvoxelsinthe80.themeanfractional………(FA)valueinthetractfrom7676MeanMeanLesionvolumeMeanMeanLesionvolumeMean語相關(guān)腦白質(zhì)基::腦結(jié)構(gòu)數(shù)據(jù)健康被試，任務(wù)態(tài)Han,Bi*,Chen,Chen,He,Caramazza,2013,TheJournalofBeauchampetal.2002,Human(n=40):Human(n=40):todecidewhetheractionswereidenticalbetweenanimationandpictureAnimal(n=30):tojudgewhethertheactioninanimationwasidenticaltothecommonactionoftheanimalinpicture.Tool(n=44): tojudgewhethertheactioninanimationwassameasthecommonactionusedthetoolinpicture.N(yr,SD,(yr,SD,BrainM: Stroke:F:(13,20-(4,2- Trauma:Mixed:Other:M: F:(11,26-(4,6-Other:Tasks:word-pictureverification,Human:actionverification(nAnimalTool HealthyRaw110121103000..................N110CorrectedcompositeCorrectedcompositeCorrect%ofeachtaskoneachpatientwerenormalizedtakingconsiderationintothedistributionofperformanceof53controls(Crawford&Garthwaite,Eachpatient’srawStandardizedt-Controlraw(forage,edu,Voxel-basedGrouVoxelG1:G0:T-testbetweenthescoresofG1andBatesetal.,2003,NatureHumanHuman&Human&&&ysesysesApproachTaskfMRI–representationPeelen*,He,Han,Caramazza,Bi*,2014,TheJournalof盲人，高級視覺加工，taskRR(Kriegeskorteetal.,––judgeisitlargerorsmallerthananaverageERdesign:8runs.Eachstimulusrepeatedtwiceeach–Sightedvisual(12goodSs,pictureSightedauditory(14goodSs,wordBlindauditory(13goodSs,word33everydayhearRepresentationAnatomically-definedAnatomically-definedBA0BAshape-blind&sightedcshape-conjunctionblind&bay-y-y-y- y-OTCnotonlyrepresentsobjectsvisually(requiringvisualOTCnotonlyrepresentsobjectsvisually(requiringvisualexperience)butalsorepresentsobjectsnonvisually,reflectingknowledgeofobjectshapeindependentlyofthemodalitythroughwhichthisknowledgewasacquired.知覺知覺訓(xùn)練前的背側(cè)初級視覺皮層ROI與前額葉聯(lián)合區(qū)體間的功能強(qiáng)度知覺訓(xùn)練前的腹側(cè)初級視覺皮層ROI與背側(cè)視覺皮層體間的功能強(qiáng)度Someissuesand完全同樣程序（e.g.,實(shí)驗(yàn)任務(wù)順序環(huán)境（e.g.,計(jì)算機(jī)；反應(yīng)鍵；光照）…可跨被試比較(betweensubject刪除刪除？Recewithmeanwithcutoffs值如何處數(shù)據(jù)指標(biāo)efficiency;PCA(component)…是否有足夠的variance?distribution是否正態(tài)？可比--havegoodpsychologistsas最常見的問題：用什么任務(wù)dependsonyourquestionclassicaltests(MMSEforgeneralcognition(patientsonly);aphasiabatteryforlanguage;s