在線網(wǎng)課知慧《藥理學(xué)(南開(kāi)大學(xué))》單元測(cè)試考核答案

第一章單元測(cè)試1【單選題】(20分)WhichofthefollowingdrugsisaninducerofCYP1A2()A.TobaccoB.CiprofloxacinC.FluconazoleD.Simvastatin2【單選題】(20分)Theprocessofrenalexcretionofdrugsdoesnotincludewhichofthefollowingoptions()A.ActivesecretionofrenaltubulesB.passivetubulereabsorptionC.GlomerularfiltrationD.Hepatoentericcirculation3【單選題】(20分)Whichofthefollowingstatementsisfalse()A.ThetimerequiredtoreachhalfofCmaxbyoraladministrationisdifferentfromthetimerequiredforhalfofCmaxintravenouslyB.Thalf（T1/2）ofadrugreferstothetimerequiredfortheplasmaconcentrationofthedrugtodropbyhalfC.AUCreferstoAreaunderthecurve(pharmacokinetics),regardingplasmadrugconcentration-timecurvesD.TmaxreferstothetimethattakesadrugorothersubstancetoreachthemaximumconcentrationCmax4.【多選題】(20分)正確答案：ABCDThemainfactorsaffectingdrugabsorptionare()A.ThefirstpasseffectB.pHC.BloodflowD.Administrationroute5【單選題】(20分)Thebioavailabilityofthedrugrefersto（）A.TherelativespeedofthedrugabsorptionintothebodyB.ThefractionorpercentageofadrugthatreacheshepaticportalcirculationC.ThefractionorpercentageofadrugthatreachestheactionpointD.Thefractionorpercentageofadrugthatreachessystemiccirculation第二章單元測(cè)試1【單選題】(20分)Whichofthefollowingoptionsiswrongabouttheantagonist()A.Antagonistaretypicallyclassifiedascompetitiveandnon-competitivB.Acompetitiveantagonistbindstothedifferentsiteastheendogenoussignalingmolecule,blockingitsbindingsiteatthereceptorC.AntagonisthavebindingaffinitytoreceptorbuttheyhavenointrinsicactivitD.Antagonistsaredrugsthatdecreaseoropposetheactionsofanotherdrugorendogenousligand2【單選題】(20分)Whichofthefollowingstatementsiswrong（）A.Thehigherthetherapeuticindex,thesaferthedrug,astheriskofatoxicorlethaloverdosedecreasB.Thepotencynotonlydependsontheefficacyofadrug,butalsoonitsbindingaffinityatthetargetsiteC.TheratioofED50toLD50istermedthetherapeuticindexanddiffersforeachdrugD.Effectivedose(ED)referstotheminimaldrugamountrequiredtoachievethemaximumeffect3【單選題】(20分)Thetherapeuticindexrefersto（）A.ED95/LD5B.ED50/LD5C.LD50/ED50D.LD5/ED954【單選題】(20分)Ifadrugbindstoareceptorandproducessomebiologicresponsesthatmimicstheresponsetotheendogenousligand,thedrugbelongsto()A.AntagonistB.AgonistC.StimulantD.Inhibitor5【單選題】(20分)Whichofthefollowingstatementsaboutthereceptoriscorrect?A.TheeffectscausedbythebindingofreceptorsandligandsoragonistsareexcitatoryeffectsB.ReceptorreferstoaproteinthatbindstoaligandandproducesameasurableresponseC.ReceptorsarepolysaccharidesonthecellmembraneD.Alldrugsworkbystimulatingorblockingthecorrespondingreceptors第三章單元測(cè)試1【單選題】(20分)Whichofthefollowingoptionsbelongstoselectiveβ1blockers()A.AtenololB.MetoprololC.AcebutololD.Labetalol2.【多選題】(20分)正確答案：BDWhichofthefollowingoptionsarelong-actingreceptoragonists?A.TerbutalineB.SalmeterolC.AlbuterolD.Formoterol3【單選題】(20分)Whichofthefollowingisananticholinesterasedrug（）A.NeostigmineB.PilocarpineC.AcetylcholineD.Carbachol4.【多選題】(20分)正確答案：ABCholinergicreceptorsinclude（）A.MuscarinicreceptorsB.NicotinicreceptorsC.βreceptorsD.αreceptors5【判斷題】(20分NicotinicreceptorsareGproteincoupledreceptors,andtheiractivationwillincreasepermeabilityofsodiumorcalciuminpostganglionicneuronsorskeletalmuscles,hencetheyarealwaysexcitatory.Istheabovestatementcorrect.A.錯(cuò)B.對(duì)第四章單元測(cè)試1【單選題】(20分)Whichofthefollowingantiarrhythmicdrugsiscardiotoxic()A.LidocaineB.VerapamilC.MagnesiumsulfateD.Digoxin2.【多選題】(20分)正確答案：ACWhichofthefollowingdrugscanbeusedforQTmonitoringofhospitalizedpatients（)A.SotalolB.AmiodaroneC.DofetilideD.Ibutilide3【單選題】(20分)AsthmaandCOPDarenotcontraindicationsforwhichofthefollowingdrugs()A.LabetalolB.MetoprololC.PindololD.Carvedilol4【單選題】(20分)Thesideeffectsofquinidinedonotincludewhichofthefollowingoptions()A.ConstipationB.DiarrheaC.lurredvisionD.Tinnitus5.【多選題】(20分)正確答案：ABCDAccordingtotheirmainmechanismofaction,antiarrhythmicdrugsincludewhichofthefollowingcategories()A.SodiumchannelblockersB.PotassiumchannelC.BlockerscalciumchannelblockersD.β-blockers第五章單元測(cè)試1【單選題】(20分)A40-year-oldmalehasrecentlybeendiagnosedwithhypertensionduetopressurereadingsof163/102and165/100mmHg.Healsohasdiabetesthatiswellcontrolledwithoralhypoglycemicmedications.Whichisthebestinitialtreatmentregimenfortreatmentofhypertensioninthispatient?A.LisinoprilandhydrochlorothiazideB.FurosemideC.FelodipineD.LisinopriE.Metoprolo2【單選題】(20分)A48-year-oldhypertensivepatienthasbeensuccessfullytreatedwithathiazidediureticforthelast5years.Overthelast3months,hisdiastolicpressurehassteadilyincreased,andhewasstartedonanadditionalantihypertensiveagent.Hecomplainsofseveralinstancesofbeingunabletoachieveanerectionandnotbeingabletocompletethreesetsoftennisasheoncedid.Whichisthelikelysecondantihypertensivemedication?A.MetoprololB.NifedipineC.LosartanD.MinoxidilE.Captopril3【單選題】(20分)Whichcanprecipitateahypertensivecrisisfollowingabruptcessationoftherapy?A.ClonidineB.LosartanC.EnalaprilD.HydrochlorothiazideE.Diltiazem4【單選題】(20分)Whichmaycausereflextachycardiaand/orposturalhypotensiononinitialadministration?A.PrazosinB.AtenololC.VerapamilD.MetoprololE.Hydrochlorothiazid5【單選題】(20分)A45-year-oldmanwasjuststartedontherapyforhypertensionanddevelopedapersistent,drycough.Whichismostlikelyresponsibleforthissideeffect?A.PrazosinB.LosartanC.NifedipinD.EnalaprilE.Propranolol第六章單元測(cè)試1【單選題】(20分)BCisa70-year-oldfemalewhoisdiagnosedwithHFrEF.Herpastmedicalhistoryissignificantforhypertensionandatrialfibrillation.Sheistakinghydrochlorothiazide,lisinopril,metoprololtartrate,andwarfarin.BCsayssheisfeeling“good”andhasnocough,shortnessofbreath,oredema.WhichisthemostappropriatemedicationchangetomakeA.DiscontinuehydrochlorothiazideB.ChangemetoprololtartratetometoprololsuccinateC.ChangelisinopriltolosartanD.Decreasewarfarindos2【單選題】(20分)Howdoβ-blockersimprovecardiacfunctioninHF?A.ByincreasingreninreleaseB.BydecreasingcardiacremodelingC.ByactivatingnorepinephrineD.Byincreasingheartrate3【單選題】(20分)WhatmakeslosartandifferentfromotherARBs?A.LosartanhasasmallvolumeofdistributionB.LosartanhasanactivemetabolitC.Losartanhastheshortesthalf-lifeD.Losartanisrenallyeliminated4【單選題】(20分)WhichbestdescribestheactionofACEinhibitorsonthefailingheart?A.ACEinhibitorsincreasevascularresistanceB.ACEinhibitorsdecreasecardiacoutpuC.ACEinhibitorsincreasealdosteronD.ACEinhibitorsreducepreload5【單選題】(20分)WhichdrugmayexacerbateHF?A.IbuprofenB.ChlorthalidoneC.AcetaminophenD.Cetirizine第七章單元測(cè)試1【單選題】(20分)Whichsideeffectisassociatedwithamlodipine?A.CoughB.BradycardiaC.EdemaD.QTprolongation2【單選題】(20分)A62-year-oldpatientwithahistoryofasthmaandvasospasticanginastatesthathegetschestpainbothwithexertionandatrest,abouttentimesperweek.Onesublingualnitroglycerintabletalwaysrelieveshissymptoms,butthismedicationgiveshimanawfulheadacheeverytimehetakesit.WhichisthebestoptionforimprovinghisanginaA.AddamlodipineB.AddpropranololC.ChangetosublingualnitroglycerinsprayD.Replacenitroglycerinwithranolazine3【單選題】(20分)A72-year-oldmalepresentstotheprimarycarecliniccomplainingofchesttightnessandpressurethatisincreasinginseverityandfrequency.Hiscurrentmedicationsincludeatenolol,lisinopril,andnitroglycerin.Whichinterventionismostappropriateatthistime?A.ReferthepatienttothenearestemergencyroomforevaluatioB.AddamlodipineC.InitiateisosorbidemononitrateD.Initiateranolazine4【單選題】(20分)Allofthefollowingmedicationscanbeusefulformanagingstableanginainapatientwithcoronaryarterydiseaseexcept:A.AtenololB.AmlodipineC.Immediate-releasenifedipineD.Isosorbidedinitrate5【單選題】(20分)Whatistheclinicaltermforanginacausedbycoronaryvasospasm?A.MyocardialinfarctionB.PrinzmetalanginaC.ClassicanginaD.Unstableangina第八章單元測(cè)試1【單選題】(20分)WhichsideeffectisassociatedwithamlodipineA.BradycardiB.EdemC.CoughD.QTprolongation2【單選題】(20分)A62-year-oldpatientwithahistoryofasthmaandvasospasticanginastatesthathegetschestpainbothwithexertionandatrest,abouttentimesperweek.Onesublingualnitroglycerintabletalwaysrelieveshissymptoms,butthismedicationgiveshimanawfulheadacheeverytimehetakesit.Whichisthebestoptionforimprovinghisangina?A.ChangetosublingualnitroglycerinsprayB.AddamlodipineC.ReplacenitroglycerinwithranolazineD.Addpropranolol3【單選題】(20分)A72-year-oldmalepresentstotheprimarycarecliniccomplainingofchesttightnessandpressurethatisincreasinginseverityandfrequency.Hiscurrentmedicationsincludeatenolol,lisinopril,andnitroglycerin.Whichinterventionismostappropriateatthistime?A.ReferthepatienttothenearestemergencyroomforevaluationB.AddamlodipineC.InitiateisosorbidemononitrateD.Initiateranolazine4【單選題】(20分)Allofthefollowingmedicationscanbeusefulformanagingstableanginainapatientwithcoronaryarterydiseaseexcept:A.Immediate-releasenifedipineB.IsosorbidedinitrateC.AtenololD.Amlodipine5【單選題】(20分)Whatistheclinicaltermforanginacausedbycoronaryvasospasm？A.UnstableanginaB.PrinzmetalanginaC.ClassicanginaD.Myocardialinfarction第九章單元測(cè)試1【單選題】(20分)WhichofthefollowingoptionsdoesnotbelongtotheclinicalapplicationofglucocorticoidsA.ForthetherapytofuberculosisB.ForthediagnosisofCushing’ssyndromeC.Foranti-inflammatory/immunosuppressivetherapyD.ReplacementtherapyforpatientswithAddison’sdisease2.【多選題】(20分)正確答案：ABCDWhichofthefollowingoptionsarecontraindicationstoglucocorticoids()A.OsteoporosisB.PepticulcerC.DiabetesD.Glaucoma3【判斷題】(20分Glucocorticoidscanbeadministeredorally,systemicallyorintra-articularly.IstheabovestatementcorrectA.錯(cuò)B.對(duì)4【單選題】(20分)Whichofthefollowingoptionsisnotanadversereactionofglucocorticoids()A.InducingworseningulcersB.InducingaggravatedinfectionC.HypoglycemiaD.Glycosuria5【單選題】(20分)Long-termuseofglucocorticoidscancause()A.HighbloodcalciumB.LowbloodpotassiumC.HighbloodphosphorusD.Highbloodpotassium第十章單元測(cè)試1【單選題】(20分)Metforminiscontraindicatedinwhichofthefollowingpatients()A.HypertensionB.GastriculcerC.RenalinsufficiencyD.Liverinsufficiency2【單選題】(20分)WhichofthefollowinghypoglycemicdrugscanNOTstimulatethepancreaticbetacellstosecreteinsulin()A.RepaglinideB.GlimepirideC.NateglinideD.Pioglitazone3.【多選題】(20分)正確答案：ACWhichofthefollowinghypoglycemicdrugsisanα-glucosidaseinhibitor()A.MiglitolB.MetforminC.AcarboseD.Canagliflozin4【單選題】(20分)Whichofthefollowingoptionsisthemostseriousadversereactionofmetformin（）A.LacticacidosisB.EdemaC.ConstipationD.Lethargy5.【多選題】(20分)正確答案：ABWhichofthefollowingdrugscancauseweightlossinpatients()A.LiraglutideB.ExenatideC.InsulinGlarginD.InsulinLispr第十一章單元測(cè)試1.【多選題】(20分)正確答案：ACDThefollowingdrugsthatcancauseleukopeniaare()A.PropylthiouraciB.IodideC.MethimazoleD.Carbimazole2【判斷題】(20分Propylthiouracil,carbimazoleandmethimazolecausesfetaltoxicities,likefetalgoiter,choanalatresia,scalpdefectsandaplasiacutis.IstheabovestatementcorrecA.對(duì)B.錯(cuò)3【單選題】(20分)Themechanismofactionofpropylthiouracilis()A.InhibitthereleaseofthyroxineB.InhibitTSHsecretionC.InhibitthyroiduptakeofiodineD.Inhibitthebiosynthesisofthyroxin4【單選題】(20分)Whichofthefollowingantithyroiddrugsisnotsuitableforchildren()A.PropylthiouracilB.IodideC.MethimazoleD.Carbimazole5【單選題】(20分)Whichofthefollowingoptionsisnotanadversereactionofpropylthiouracil()A.JointpainB.RashC.FetaltoxicityD.Hypothyroidism第十二章單元測(cè)試1【單選題】(20分)Followingisthemaininhibitorytransmitterinthebrain()A.GlycineB.GABAC.DopamineD.Norepinephrine2.【多選題】(20分)正確答案：ABCDWhichoneofthefollowingchemicalsdoessatisfythecriteriaforaneurotransmitterroleintheCNS?A.AcetylcholineB.GlycineC.DopamineD.SubstancePE.NitricOxide3【單選題】(20分)FollowingisaG-proteincoupledreceptor()A.KainateB.NMDAC.MetabotropicD.AMPA4【單選題】(20分)Neurotransmittersmay()A.IncreasecalciumconductancetocauseinhibitionB.IncresesodiumconductancetocauseinhibitionC.IncreasechlorideconductancetocauseinhibitionD.Increasepotassiumconductancetocauseexcitation5【單選題】(20分)Substancesecretedintothebloodbyaneuronis()A.NeuromediatorB.NeurotransmitterC.NeuromodulatorD.Neurohormone第十三章單元測(cè)試1【單選題】(20分)WhichagentisbestusedintheEmergencyRoomsettingforpatientswhoarebelievedtohavereceivedtoomuchofabenzodiazepinedrugortakenanoverdoseofbenzodiazepines?A.NaloxoneB.FlumazenilC.DoxepinD.DiazepamE.Ramelteon2【單選題】(20分)FollowingisGABAAagonist()A.MuscimolB.BicucullineC.BaclofenD.Noneoftheabove3【單選題】(20分)Themostlikelyexplanationfortheincreasedsensitivityofelderlypatientstoasingledoseoftriazolamandothersedative-hypnoticdrugsis()A.DecreasedrenalfunctionB.DecreasedhepaticmetabolismoflipidsolubledrugsC.ChangesinplasmaproteinbindingD.ChangesinbrainfunctionthataccompanytheagingprocessE.Increasedcerebralbloodflow4.【多選題】(20分)正確答案：ABDEWhichoneofthefollowingstatementsiswrongregardingtheanxiolyticandhypnoticagents?A.Phenobarbitalisusefulinthetreatmentofacuteintermittentporphyria.B.Phenobarbitalshowsanalgesicproperties.C.Phenobarbitalinducesrespiratorydepression,whichisenhancedbytheconsumptionofethanol.D.DiazepamandphenobarbitalinducethecytochromeP450enzymesystem.E.Buspironehasactionssimilartothoseofthebenzodiazepines.5【單選題】(20分)Whichoneofthefollowingstatementsiscorrectregardingbenzodiazepines?A.Benzodiazepinesshowanalgesicactions.B.Allbenzodiazepineshavesomesedativeeffects.C.Clinicalimprovementofanxietyrequires2to4weeksoftreatmentwithbenzodiazepines.D.Benzodiazepines,likeotherCNSdepressants,readilyproducegeneralanesthesia.E.Benzodiazepinesdirectlyopenchloridechannels.第十四章單元測(cè)試1【單選題】(20分)Followinggeneralanestheticisnotmetabolized()A.NitrousoxideB.HalothaneC.IsofluraneD.Ether2【單選題】(20分)Fourstagesofgeneralanesthesiaaredistinctlyseenwiththeuseof()A.NitrousoxideB.EnfluraneC.HalothaneD.Diethylether3【單選題】(20分)Apatientwithheartfailureandsignificantlyreducedcardiacoutputrequiressurgicalanesthesia.Whichofthefollowingwouldyouexpecttoseeinthispatient?A.SlowerinductiontimewithIVanestheticsB.EnhancedremovalofinhaledanestheticstoperipheraltissuesC.NeedforincreaseddosageofIVanestheticsD.Slowerinductiontimewithinhaledanesthetics4【單選題】(20分)Whichoneofthefollowingisapotentintravenousanestheticbutaweakanalgesic?A.PropofolB.IsofluraneC.BenzodiazepinesD.FentanylE.Ketamine5【單選題】(20分)Whichofthefollowingisapotentanalgesicbutaweakanesthetic?A.MidazolamB.HalothanC.EtomidateD.NitrousoxidE.Thiopenta第十五章單元測(cè)試1【單選題】(20分)Aprominenttoxiceffectoflocalanaestheticsis()A.LocalischemiaB.CNSstimulationC.NoneoftheaboveD.TachycardiaE.CNSdepression2【單選題】(20分)A32-year-oldwomanrequestsanepiduraltoeaselaborpains.ShereportsthatshehadanallergicreactiontoNovocain(procaine)atthedentist’soffice.Whichofthefollowinglocalanestheticswouldbeappropriateforuseinanepiduralforthispatient?A.Tetracaine.B.Chloroprocaine.C.Mepivacaine.D.Ropivacaine.3.【多選題】(20分)正確答案：ACDEToxicitiesoflocalanaestheticsinclude()A.Convulsions(lidocaine)B.Hypertensiveemergencies,strokes(procaine)C.Cardiovasculararrhythmiasandcollapse(bupivacaine)D.MethemoglobinemiaE.Dizziness,sedation(lidocaine)4.【多選題】(20分)正確答案：ABCDWhichofthefollowingiswrongregardinglocalanesthetics?A.Intheirionizedform,theyinteractwiththeproteinreceptorofcalciumchannels.B.Theyhaveeitheralipophilicorahydrophilicgroup.C.TheyareunaffectedbypHofthetissueandpKaofthedrug.D.Theyaffectonlysmall,unmyelinatednervefibers.E.Theyhaveeitheranamideoranesterlinkage.5【單選題】(20分)Whichoneofthefollowingstatementsaboutthetoxicityoflocalanaestheticsismostcorrect?A..IntravenousinjectionoflocalanaestheticsmaystimulateectopiccardiacpacemakeractivityB.Cyanosismayoccurfollowinginjectionoflargedosesoflidocaine,especiallyinpatientswithpulmonarydiseaseC.Inoverdosage,hyperventilation(withoxygen)ishelpfultocorrectacidosisandlowerextracellularpotassiumD.SeriouscardiovascularreactionsaremorelikelytooccurwithtetracainethanwithbupivacaineE.Mostlocalanaestheticscausevasoconstriction第十六章單元測(cè)試1【單選題】(20分)Whichofthefollowingdrugsismostusefulforthetreatmentofabsenceseizures?（）A.Lamotrigine.B.Levetiracetam.C.Topiramate.D.Tiagabine.E.Zonisamide.2【單選題】(20分)Whichofthefollowingisafirst-linemedicationforgeneralizedtonic–clonicseizures?（）A.Ezogabine.B.Vigabatrin.C.Topiramate.D.Felbamate.E.Ethosuximide.3【單選題】(20分)A9-year-oldboyissentforneurologicevaluationbecauseofepisodesofapparentinattention.Overthepastyear,thechildhasexperiencedepisodesduringwhichhedevelopsablanklookonhisfaceandhiseyesblinkfor15seconds.Heimmediatelyresumeshispreviousactivity.Whichonethefollowingbestdescribesthispatient’sseizures?（）A.Absence.B.Complexpartial.C.Simplepartial.D.Myoclonic.E.Tonic–clonic.4【單選題】(20分)A25-year-oldwomanwithmyoclonicseizuresiswellcontrolledonvalproate.Sheindicatesthatsheisinterestedinbecomingpregnantinthenextyear.Withrespecttoherantiepilepsymedication,whichofthefollowingshouldbeconsidered?（）A.Considerswitchingtolamotrigine.B.Leaveheronhercurrenttherapy.C.Consideraddingasecondantiepilepsymedication.D.Decreasehervalproatedose.5【單選題】(20分)Apatientwithfocalcomplexpartialseizureshasbeentreatedfor6monthswithcarbamazepinebut,recently,hasbeenexperiencingbreakthroughseizuresonamorefrequentbasis.Youareconsideringaddingaseconddrugtotheantiseizureregimen.Whichofthefollowingdrugsisleastlikelytohaveapharmacokineticinteractionwithcarbamazepine?（）A.Tiagabine.B.Levetiracetam.C.Lamotrigine.D.Zonisamide.E.Topiramate.第十七章單元測(cè)試1【單選題】(20分)Insmallintestine,morphineparticularlyaffects()A.DuodenumB.IleumC.Doesnotaffectsmallintestin2.【多選題】(20分)正確答案：ACDWhichofthefollowingstatementsregardingmethadoneiswrong?A.Theactivemetabolitesofmethadoneaccumulateinpatientswithrenaldysfunction.B.Thedurationofanalgesiaformethadoneismuchshorterthantheeliminationhalf-life.C.Methadoneisanexcellentchoiceforanalgesiainmostpatientssincetherearelimiteddrug–druginteractions.D.Theequianalgesicpotencyofmethadoneissimilartothatofmorphine.3【單選題】(20分)WhichofthefollowingopioidsistheLEASTlipophilic?A.Meperidine.B.Morphine.C.Fentanyl.D.Methadone.4【單選題】(20分)正確答案：EMorphinestimulates()A.HumanuterusatfulltermB.PropulsivecontractionsinsmallintestineofmanC.BillaryandpancreaticsecretionsD.PropulsiveperistalticwavesincolonE.Nonpropulsiverhythmiccontractionsofsmallintestineofman5【單選題】(20分)Whichofthefollowingstatementsaboutfentanyliscorrect?A.Theactivemetabolitesoffentanylcancauseseizures.B.Itswithdrawalsymptomscanberelievedbynaloxone.C.Fentanylis100timesmorepotentthanmorphine.D.Itismosteffectivebyoraladministration.第十八章單元測(cè)試1【單選題】(20分)Analgesiceffectsofaspirin:A.bothB.peripheralaction(inflammation)C.neitherD.subcorticalsiteofactio2【單選題】(20分)正確答案：ENSAIDprimarilypromotedasananalgesic,notasananti-inflammatoryagent:A.IbuprofenB.PiroxicamC.NaproxenD.sulindacE.Ketorolac3【單選題】(20分)正確答案：ENSAIDprimarilypromotedasananalgesic,notasananti-inflammatoryagent:A.sulindacB.naproxenC.piroxicamD.ibuprofenE.ketorola4【單選題】(20分)Mediatormostlikelytopromotepain()A.bradykininB.prostaglandinsC.serotoninD.histamineE.leukotrienes5【單選題】(20分)Mechanismofaction:aspirin-plateleteffects:A.bothB.promotesplateletaggregationC.neitherD.activatesthromboxanesynthesis第十九章單元測(cè)試1【單選題】(20分)Antihistamines,phenothiazines,tricyclicantidepressantsandantiparkinsonianagentshaveacommonpropertythat()A.AllhavesomeatropinelikeactionB.AllproducesCNSstimulationC.AllhaveadrenergicactionD.Allhavelongplasmahalf-life2【單選題】(20分)Peripheraladverseeffectsoflevodopa,includingnausea,hypotension,andcardiacarrhythmias,canbediminishedbyincludingwhichofthefollowingdrugsinthetherapy?A.Amantadine.B.Ropinirole.C.Carbidopa.D.Tolcapone.E.Pramipexole.3【單選題】(20分)WhichmedicationisaglutamatereceptorantagonistthatcanbeusedincombinationwithanacetylcholinesteraseinhibitortomanagethesymptomsofAlzheimer’sdisease?A.Rivastigmine.B.Ropinirole.C.Donepezil.D.Memantine.E.Fluoxetine.4【單選題】(20分)Tolerancetotheantiparkinsonianactiondevelopsmostrapidlyinthecaseof()A.LevodopaB.Levodopa+carbidopaC.AmantadineD.Bromocriptine5【單選題】(20分)Theantiparkinsoniandrugwhichactsbyinhibitingthedegradationofdopamineinthebrainis()A.AmantadineB.BromocriptineC.CarbidopaD.Selegiline第二十章單元測(cè)試1【單選題】(20分)Whichantipsychotichasthemostsedativepotentialandissometimesquestionablyusedasahypnoticagentincertainclinicalsettings?A.Iloperidone.B.Quetiapine.C.Thiothixene.D.HaloperidolE.Fluphenazine.2【單選題】(20分)WhichoneofthefollowingantipsychoticshasbeenshowntobeapartialagonistatthedopamineD2receptor?A.Aripiprazole.B.HaloperidolC.Clozapine.D.Thioridazine.E.Risperidone.3【單選題】(20分)Whichantidepressanthas,asitstwoprinciplemechanismsofaction,5-HT2Areceptorantagonismandα2receptorantagonism?A.Fluoxetine.B.Maprotiline.C.Doxepin.D.MirtazapineE.Selegiline.4【單選題】(20分)Whichantidepressantisthemostsedating?A.Nortriptyline.B.CitalopramC.Fluoxetine.D.Duloxetine.E.Venlafaxine.5【單選題】(20分)Whichantidepressanthas,asitstwoproposedprinciplemechanismsofaction,5-HT1areceptorpartialagonismand5-HTreuptakeinhibition?A.Aripiprazole.B.Vilazodone.C.Mirtazapine.D.Maprotiline.E.Fluoxetine.第二十一章單元測(cè)試1【單選題】(20分)Recreationaluseofdrugssometimesleadstodependence.Whichofthefollowingisleastlikelytocausephysicaldependence?A.AlcoholhasadirectstimulatoryeffectonsexualresponsivenessB.AlcoholisteratogenicC.AlcoholincreasesADAproductionD.Alcoholisexcitatoryinnature2【單選題】(20分)Mentalretardation,microcephaly,andunderdevelopmentofthemidfaceregioninaninfantisassociatedwithchronicmaternalabuseof（）A.MescalineB.EthanolC.CocaineD.AmphetamineE.Phencyclidine3【單選題】(20分)A35-year-oldmanhasbeenabusingcocaineandisagitated,tachycardic,hypertensive,andhyperthermic.Whichofthefollowingiscorrectregardingtreatmentinthissituation?A.CocainetoxicitycommonlyinvolvesCNSdepressionthatcanbereversedwithIVatropine.B.PhenobarbitalshouldbethefirstchoiceasananticonvulsantC.Thispatientshouldundergogastriclavage;thatis,heshouldhavehisstomachpumpedimmediately.D.Benzodiazepineswouldbeag