Pheniramine-maleate-Standard-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors ? ScreeningLibraries ? Proteinswww.MedChemEPheniramine(maleate)(Standard)Cat.No.:HY-B0971RCASNo.:132-20-7分子式:C??H??N?O?分子量:356.42作用靶點(diǎn):HistamineReceptor;Apoptosis作用通路:GPCR/GProtein;Immunology/Inflammation;NeuronalSignaling;Apoptosis儲存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性 Pheniramine(maleate)(Standard)是Pheniramine(maleate)的分析標(biāo)準(zhǔn)品。本產(chǎn)品用于研究及分析應(yīng)用。Pheniramine(Prophenpyridamine;Tripoton)maleate是第一代組胺H1受體拮抗劑，作用于中樞神經(jīng)系統(tǒng)(CNS)，產(chǎn)生鎮(zhèn)靜、助眠的作用。Pheniraminemaleate也是安全、有效的局部活性劑，可抑制或緩解疼痛，并有止癢作用。IC50&Target Target:histamineH1ReceptorAntagonist[1],apoptosisi[3]REFERENCESSharmaA,etal.ClassichistamineH1receptorantagonists:acriticalreviewoftheirmetabolicandpharmacokineticfatefromabird'seyeview.CurrDrugMetab.2003Apr;4(2):105-29.BrownRD,etal.Alpha1-adrenergicandH1-histaminereceptorcontrolofintracellularCa2+inamusclecellline:theinfluenceofprioragonistexposureonreceptorresponsiveness.MolPharmacol.1986Jun;29(6):531-9.JangiSM,etal.ApoptosisofhumanT-cellacutelymphoblasticleukemiacellsbydiphenhydramine,anH1histaminereceptorantagonist.OncolRes.2004;14(7-8):363-72.HungCH,etal.Spinalanesthesiawithdiphenhydramineandpheniramineinrats.EurJPharmacol.2011Dec30;673(1-3):20-4.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792Fax: