Sodium-orthovanadate-Sodium-vanadate-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemESodium orthovanadateCat. No.: HY-D0852CAS No.: 13721-39-6Synonyms: Sodium vanadate分式: NaOV分量: 183.91作靶點(diǎn): Phosphatase作通路: Metabolic Enzyme/Protease儲(chǔ)存式: 4C, protect from light* In solvent : -80C, 6 months; -20C, 1 month (protect f

2、romlight)溶解性數(shù)據(jù)體外實(shí)驗(yàn) H2O : 200 mg/mL (1087.49 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 5.4374 mL 27.1872 mL 54.3744 mL5 mM 1.0875 mL 5.4374 mL 10.8749 mL10 mM 0.5437 mL 2.7187 mL 5.4374 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。BIOLOGICAL ACTIVI

3、TY物活性 Sodium orthovanadate蛋酪氨酸磷酸酶，堿性磷酸酶和些ATP酶的抑制劑，最有可能充當(dāng)磷酸鹽類似物。IC50 & Target PPTPase 1.體外研究In the presence of oxidizing agents vanadium ions exist as the hydrated monomer of Sodium orthovanadate1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE(vanadate: HVO42- or H2VO4-) at micromolar concentations

4、near neutral pH. Sodium orthovanadate(vanadate) also begins to polymerize at concentrations greater than 0.1 mM at neutral pH. The yellow-orangesolutions of decavanadate can be converted to the colorless solutions of monomeric Sodium orthovanadate(vanadate) by dilution after a period of many hours.

5、The process is hastened by boiling at pH 10, whichencourages the kinetically sluggish depolymerization process 1. Sodium orthovanadate could alter thephosphorylation status of ASK1 at serine 83 and threonine 845 induced by ischemia. Sodium orthovanadatecould increase the tyrosine posphorylation of P

6、TEN and further inhibit the activation of ASK1 via activatingAkt during cerebral ischemia 2.REFERENCES1. Gordon JA, et al. Use of vanadate as protein-phosphotyrosine phosphatase inhibitor. Methods Enzymol. 1991;201:477-82.2. Wu DN, et al. Down-regulation of PTEN by sodium orthovanadate inhibits ASK1 activation via PI3-K/Akt during cerebral ischemia in rathippocampus. Neurosci Lett. 2006 Aug 14;404(1-2):98-102.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.T