Doxepin-Hydrochloride _Serotonin Transporter 抑制劑 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEDoxepin HydrochlorideCat. No.: HY-B0725CAS No.: 1229-29-4分式: CHClNO分量: 315.84作靶點(diǎn): Serotonin Transporter作通路: Neuronal Signaling儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 100 mg/mL (316.

2、62 mM)H2O : 50 mg/mL (158.31 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 3.1662 mL 15.8308 mL 31.6616 mL5 mM 0.6332 mL 3.1662 mL 6.3323 mL10 mM 0.3166 mL 1.5831 mL 3.1662 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。體內(nèi)實(shí)驗(yàn)請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥式選擇適當(dāng)?shù)娜芙獍福渲魄罢?qǐng)先配制

3、澄清的儲(chǔ)備液，再依次添加助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請(qǐng)依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (7.92 mM); Clear solution2. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (7.92 mM); Clear solution1/2 Mas

4、ter of Small Molecules 您邊的抑制劑師www.MedChemE3. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (7.92 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Doxepin Hydrochloride 能抑制 5-羥胺和去甲腎上腺素的重 吸收，有抗抑郁活性。REFERENCES1. /pdsp.php2. Hajak, G., et al., Doxepin in the treatment of primary insomnia: a placebo-controlled, double-blind, polysomnographic study. J ClinPsychiatry, 2001. 62(6): p. 453-63.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;