Bcl-2-Family-Inhibitors-Modulators-MCE

1、 HYPERLINK https:/www.MedChemE/Targets/Bcl-2 Family.html Bcl-2 HYPERLINK https:/www.MedChemE/Targets/Bcl-2 Family.html HYPERLINK https:/www.MedChemE/Targets/Bcl-2 Family.html FamilyBcl-2 is a family of evolutionarily related proteins. These proteins govern mitochondrial outer membrane permeabilizati

2、on (MOMP)and can be either pro-apoptotic (Bax, Bad, Bak and Bok among others) or anti-apoptotic (including Bcl-2 proper, Bcl-xL, and Bcl-w,among an assortment of others). There are a total of 25 genes in the Bcl-2 family known to date. Human genes encoding proteinsthat belong to this family include:

3、 Bak1, Bax, Bal-2, Bok, Mcl-1.www.MedChemE 12 Tel: 609-228-6898 Fax: 609-228-5909 Email: salesMedChemE HYPERLINK https:/www.MedChemE/Targets/Bcl-2 Family.html Bcl-2 HYPERLINK https:/www.MedChemE/Targets/Bcl-2 Family.html HYPERLINK https:/www.MedChemE/Targets/Bcl-2 Family.html Family HYPERLINK https:

4、/www.MedChemE/Targets/Bcl-2 Family.html HYPERLINK https:/www.MedChemE/Targets/Bcl-2 Family.html Inhibitors, HYPERLINK https:/www.MedChemE/Targets/Bcl-2 Family.html HYPERLINK https:/www.MedChemE/Targets/Bcl-2 Family.html Antagonists, HYPERLINK https:/www.MedChemE/Targets/Bcl-2 Family.html HYPERLINK h

5、ttps:/www.MedChemE/Targets/Bcl-2 Family.html Activators, HYPERLINK https:/www.MedChemE/Targets/Bcl-2 Family.html HYPERLINK https:/www.MedChemE/Targets/Bcl-2 Family.html Modulators HYPERLINK https:/www.MedChemE/Targets/Bcl-2 Family.html HYPERLINK https:/www.MedChemE/Targets/Bcl-2 Family.html & HYPERL

6、INK https:/www.MedChemE/Targets/Bcl-2 Family.html HYPERLINK https:/www.MedChemE/Targets/Bcl-2 Family.html Inducers HYPERLINK https:/www.MedChemE/_addition_-Apogossypol.html (+)-Apogossypol(Apogossypol; NSC736630) Cat. No.: HY-13408 HYPERLINK https:/www.MedChemE/e-ferulic-acid.html (E)-Ferulic HYPERL

7、INK https:/www.MedChemE/e-ferulic-acid.html HYPERLINK https:/www.MedChemE/e-ferulic-acid.html acid(E)-Coniferic acid) Cat. No.: HY-N0060B(+)-Apogossypol is a pan-BCL-2 antagonist.(+)-Apogossypol binds to Mcl-1, Bcl-2 and Bcl-xLwith EC s of 2.6, 2.8 and 3.69 M,50respectively.(E)-Ferulic acid is a iso

8、mer of Ferulic acid whichis an aromatic compound, abundant in plant cellwalls.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 99.20%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 100 mg HYPERLINK https:/www.MedChemE/e-ferulic-acid-d3.html (E)-Ferulic HYPERLINK https

9、:/www.MedChemE/e-ferulic-acid-d3.html HYPERLINK https:/www.MedChemE/e-ferulic-acid-d3.html acid-d3(E)-Coniferic acid-d3) Cat. No.: HY-N0060BS HYPERLINK https:/www.MedChemE/AT-101.html (R)-(-)-Gossypol(AT-101; R-(-)-gossypol acetic acid) Cat. No.: HY-15464(E)-Ferulic acid-d3 (E)-Coniferic acid-d3) is

10、 thedeuterium labeled (E)-Ferulic acid. (E)-Ferulicacid is a isomer of Ferulic acid which is anaromatic compound, abundant in plant cell walls.(R)-(-)-Gossypol (AT-101) is the levorotatoryisomer of a natural product Gossypol. AT-101 isdetermined to bind to Bcl-2, Mcl-1 and Bcl-xLproteins with Ks of

11、26030 nM, 17010 nM, andi48040 nM, respectively.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98%Clinical Data: Phase 2Size: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/AT-101-acetic-acid.html (R)-(-)-Gossypol HYPERLINK https:/www.MedChemE/AT-101-acetic-acid.html HYPERLINK htt

12、ps:/www.MedChemE/AT-101-acetic-acid.html acetic HYPERLINK https:/www.MedChemE/AT-101-acetic-acid.html HYPERLINK https:/www.MedChemE/AT-101-acetic-acid.html acid HYPERLINK https:/www.MedChemE/AT-101-acetic-acid.html (AT-101 (acetic acid);(-)-Gossypol acetic acid; (R)-Gossypol acetic acid) Cat. No.: H

13、Y-15464A HYPERLINK https:/www.MedChemE/r-mik665.html (R)-MIK665Cat. No.: HY-112218A(R)-(-)-Gossypol acetic acid (AT-101 (aceticacid) is the levorotatory isomer of a naturalproduct Gossypol. AT-101 is determined to bind toBcl-2, Mcl-1 and Bcl-xL proteins with Ks ofi26030 nM, 17010 nM, and 48040 nM, r

14、espectively.(R)-MIK665 is the less active enantiomer ofMIK665. MIK665 is a special Mcl-1 inhibitor withan IC of 1.81 nM.50Purity: 98.02%Clinical Data: Phase 2Size: 10 mM 1 mL, 10 mg, 50 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/_S_-Gossypol-ace

15、tic-acid.html (S)-Gossypol HYPERLINK https:/www.MedChemE/_S_-Gossypol-acetic-acid.html HYPERLINK https:/www.MedChemE/_S_-Gossypol-acetic-acid.html (acetic HYPERLINK https:/www.MedChemE/_S_-Gossypol-acetic-acid.html HYPERLINK https:/www.MedChemE/_S_-Gossypol-acetic-acid.html acid) HYPERLINK https:/ww

16、w.MedChemE/_S_-Gossypol-acetic-acid.html HYPERLINK https:/www.MedChemE/2-hydroxychalcone.html 2-Hydroxychalcone(S)-(+)-Gossypol acetic acid) Cat. No.: HY-15464DCat. No.: HY-119931(S)-Gossypol is the isomer of a natural productGossypol. (S)-Gossypol binds to the BH3-bindinggroove of Bcl-xL and Bcl-2

17、proteins with highaffinity.2-hydroxychalcone, a natural flavonoid, is apotent antioxidant, inhibiting lipid peroxidation.2-Hydroxychalcone induces apoptosis by Bcl-2downregulation. 2-Hydroxychalcone inhibits theactivation of NF-kB.Purity: 99.01%Clinical Data: No Development ReportedSize: 10 mM 1 mL,

18、 10 mg, 50 mg, 100 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/A-1155463.html A-1155463 HYPERLINK https:/www.MedChemE/A-1155463.html HYPERLINK https:/www.MedChemE/A-1210477.html A-1210477Cat. No.: HY-19725 Cat. No.: HY-12468A-1155463 is a highly

19、potent and selective BCL-XLinhibitor with an EC of 70 nM in Molt-4 cell.50A-1210477 is a potent and selective inhibitor ofMCL-1 with a K of 0.45 nM. A-1210477ispecifically binds MCL-1 and promotes apoptosis ofcancer cells in an MCL-1-dependent manner.Purity: 99.51%Clinical Data: No Development Repor

20、tedSize: 10 mM 1 mL, 5 mg, 10 mg, 50 mg, 100 mgPurity: 98.89%Clinical Data: No Development ReportedSize: 5 mg, 10 mg, 25 mg, 50 mg, 100 mgwww.MedChemE 3 HYPERLINK https:/www.MedChemE/A-1331852.html A-1331852 HYPERLINK https:/www.MedChemE/A-1331852.html HYPERLINK https:/www.MedChemE/A-385358.html A-3

21、85358Cat. No.: HY-19741 Cat. No.: HY-16014A-1331852 is an orally available BCL-XL selectiveinhibitor with a K of less than 10 pM.iA-385358 is a selective inhibitor of Bcl-X withLKis of 0.80 and 67 nM for Bcl-XL and Bcl-2,respectively.Purity: 99.65%Clinical Data: No Development ReportedSize: 10 mM 1

22、mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mgPurity: 98.63%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg HYPERLINK https:/www.MedChemE/abbv-167.html ABBV-167 HYPERLINK https:/www.MedChemE/abbv-167.html HYPERLINK https:/www.MedChemE/abt-737-d8.html ABT HYPERLINK ht

23、tps:/www.MedChemE/abt-737-d8.html HYPERLINK https:/www.MedChemE/abt-737-d8.html 737-d8Cat. No.: HY-142209 Cat. No.: HY-50907SABBV-167 is a phosphate prodrug of the BCL-2inhibitor venetoclax.ABT 737-d8 is the deuterium labeled ABT-737.ABT-737, a BH3 mimetic, is a potent Bcl-2, Bcl-xLand Bcl-w inhibit

24、or with EC s of 30.3 nM,5078.7 nM, and 197.8 nM, respectively.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 10 mg HYPERLINK https:/www.MedChemE/abt-737.html ABT-737 HYPERLINK https:/www.MedChemE/abt-737.html HYPERLINK ht

25、tps:/www.MedChemE/anticancer-agent-43.html Anticancer HYPERLINK https:/www.MedChemE/anticancer-agent-43.html HYPERLINK https:/www.MedChemE/anticancer-agent-43.html agent HYPERLINK https:/www.MedChemE/anticancer-agent-43.html HYPERLINK https:/www.MedChemE/anticancer-agent-43.html 43Cat. No.: HY-50907

26、 Cat. No.: HY-146548ABT-737, a BH3 mimetic, is a potent Bcl-2, Bcl-xLand Bcl-w inhibitor with EC s of 30.3 nM,5078.7 nM, and 197.8 nM, respectively. ABT-737induces the disruption of the BCL-2/BAX complexand BAK-dependent but BIM-independent activationof the intrinsic apoptotic pathway.Anticancer Age

27、nt 43 is a potent anticancer agent.Anticancer Agent 43 induces apoptosis by caspase 3,PARP1, and Bax dependent mechanisms. AnticancerAgent 43 induces DNA damage.Purity: 99.72%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 5 mg, 10 mg, 50 mg, 100 mg, 200 mgPurity: 98%Clinical Data: No Develo

28、pment ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/antitumor-agent-55.html Antitumor HYPERLINK https:/www.MedChemE/antitumor-agent-55.html HYPERLINK https:/www.MedChemE/antitumor-agent-55.html agent-55 HYPERLINK https:/www.MedChemE/antitumor-agent-55.html HYPERLINK https:/www.MedChemE/apog

29、ossypolone.html ApogossypoloneCat. No.: HY-146038(ApoG2) Cat. No.: HY-19551Antitumor agent-55 (compound 5q) is a potentantitumor agent. Antitumor agent-55 effectivelyinhibits PC3, with an IC of 0.91 M. Antitumor50agent-55 effectively inhibits the colonyformation, suppresses the cell migration in PC3

30、.Apogossypolone (ApoG2) is an orally active Bcl-2family proteins inhibitor with K values of 35, 25iand 660 nM for Bcl-2, Mcl-1 and Bcl-X ,Lrespectively. Apogossypolone shows antitumoractivities, induces cell apoptosis and autophagy.Apogossypolone also has antifungal activity.Purity: 98%Clinical Data

31、: No Development ReportedSize: 1 mg, 5 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/AZD-5991.html AZD-5991 HYPERLINK https:/www.MedChemE/AZD-5991.html HYPERLINK https:/www.MedChemE/AZD-5991_S-enantiomer.html AZD-5991 HYPERLINK https:/www.MedChemE/

32、AZD-5991_S-enantiomer.html HYPERLINK https:/www.MedChemE/AZD-5991_S-enantiomer.html (S-enantiomer)Cat. No.: HY-101533 Cat. No.: HY-101533BAZD-5991 is a potent and selective Mcl-1inhibitor with an IC of 0.7 nM in FRET assay and50a K of 0.17 nM in surface plasmon resonanced(SPR) assay.AZD-5991 S-enant

33、iomer is the less activeenantiomer of AZD-5991. AZD-5991 S-enantiomer is aMcl-1 inhibitor with an IC of 6.3 M in FRET50assay and a K of 0.98 M in surface plasmondresonance (SPR) assay.Purity: 99.50%Clinical Data: Phase 2Size: 10 mM 1 mL, 5 mg, 10 mg, 50 mgPurity: 98%Clinical Data: No Development Rep

34、ortedSize: 1 mg, 5 mg4 Tel: 609-228-6898 Fax: 609-228-5909 Email: salesMedChemE HYPERLINK https:/www.MedChemE/AZD-5991_Racemate.html AZD-5991 HYPERLINK https:/www.MedChemE/AZD-5991_Racemate.html HYPERLINK https:/www.MedChemE/AZD-5991_Racemate.html Racemate HYPERLINK https:/www.MedChemE/AZD-5991_Race

35、mate.html HYPERLINK https:/www.MedChemE/AZD4320.html AZD4320Cat. No.: HY-101533A Cat. No.: HY-112416AZD-5991 Racemate is the racemate of AZD-5991.AZD-5991 Racemate is a Mcl-1 inhibitor with anIC of 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 99.10%Clinical Data: No Development R

36、eportedSize: 10 mM 1 mL, 5 mg, 10 mg, 50 mg, 100 mg HYPERLINK https:/www.MedChemE/bad-103-127-human.html BAD HYPERLINK https:/www.MedChemE/bad-103-127-human.html HYPERLINK https:/www.MedChemE/bad-103-127-human.html (103-127) HYPERLINK https:/www.MedChemE/bad-103-127-human.html HYPERLINK https:/www.M

37、edChemE/bad-103-127-human.html (human) HYPERLINK https:/www.MedChemE/bad-103-127-human.html HYPERLINK https:/www.MedChemE/bad-103-127-human-fam-labeled.html BAD HYPERLINK https:/www.MedChemE/bad-103-127-human-fam-labeled.html HYPERLINK https:/www.MedChemE/bad-103-127-human-fam-labeled.html (103-127)

38、 HYPERLINK https:/www.MedChemE/bad-103-127-human-fam-labeled.html HYPERLINK https:/www.MedChemE/bad-103-127-human-fam-labeled.html (human), HYPERLINK https:/www.MedChemE/bad-103-127-human-fam-labeled.html HYPERLINK https:/www.MedChemE/bad-103-127-human-fam-labeled.html FAM-labeledCat. No.: HY-P2468

39、Cat. No.: HY-P2499BAD (103-127) (human), the 25-mer Bad peptide, isderived from the BH3 domain of BAD, can antagonizethe function of Bcl-xL. BAD (103-127) (human) isreported to have almost 800-fold higher affinityfor Bcl-XL than the 16-mer peptide.BAD (103-127) (human), FAM-labeled is aFAM-labeled h

40、uman BAD (103-127) (HY-P2468). BAD(103-127) (human), the 25-mer Bad peptide, isderived from the BH3 domain of BAD, can antagonizethe function of Bcl-xL.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/

41、www.MedChemE/BAI1.html BAI1 HYPERLINK https:/www.MedChemE/BAI1.html HYPERLINK https:/www.MedChemE/Bak_BH3.html Bak HYPERLINK https:/www.MedChemE/Bak_BH3.html HYPERLINK https:/www.MedChemE/Bak_BH3.html BH3Cat. No.: HY-103269 Cat. No.: HY-P0300BAI1 is a selective and allosteric inhibitor ofBAX, an apo

42、ptosis regulator. BAI1 directly bindsto BAX and allosterically inhibits BAX activation.BAI1 has the potential for the research ofdiseases mediated by BAX-dependent cell death.Bak BH3 is derived from the BH3 domain of Bak, canantagonize the function of Bcl-xL in cells.Purity: 99.73%Clinical Data: No

43、Development ReportedSize: 10 mM 1 mL, 5 mg, 10 mg, 50 mg, 100 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg, 10 mg HYPERLINK https:/www.MedChemE/bam7.html BAM7 HYPERLINK https:/www.MedChemE/bam7.html HYPERLINK https:/www.MedChemE/bax-activator-1.html Bax HYPERLINK https:/www.Me

44、dChemE/bax-activator-1.html HYPERLINK https:/www.MedChemE/bax-activator-1.html activator-1Cat. No.: HY-15341 Cat. No.: HY-122760BAM7 is a direct and selective activator ofproapoptotic BAX with an IC of 3.3 M.50Bax activator-1 (compound 106) is a Bax activatorthat induces Bax-dependent tumor cell apo

45、ptosis.Purity: 99.18%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 10 mg, 50 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/Bax-inhibitor-peptide-V5.html Bax HYPERLINK https:/www.MedChemE/Bax-inhibitor-peptide-V5.html HYPERLINK https:/www.

46、MedChemE/Bax-inhibitor-peptide-V5.html inhibitor HYPERLINK https:/www.MedChemE/Bax-inhibitor-peptide-V5.html HYPERLINK https:/www.MedChemE/Bax-inhibitor-peptide-V5.html peptide HYPERLINK https:/www.MedChemE/Bax-inhibitor-peptide-V5.html HYPERLINK https:/www.MedChemE/Bax-inhibitor-peptide-V5.html V5

47、HYPERLINK https:/www.MedChemE/Bax-inhibitor-peptide-V5.html HYPERLINK https:/www.MedChemE/bcl-2-in-2.html Bcl-2-IN-2(BIP-V5; BAX Inhibiting Peptide V5) Cat. No.: HY-P0081Cat. No.: HY-131247Bax inhibitor peptide V5 (BIP-V5) is aBax-mediated apoptosis inhibitor, used forcancer treatment.Bcl-2-IN-2 is

48、a potent and selective Bcl-2inhibitor with an IC of 0.034 nM and also50inhibits Bcl-xL with an IC of 43 nM, showing501000-fold selectivity for Bcl-2 over Bcl-xL.Purity: 98.12%Clinical Data: No Development ReportedSize: 5 mg, 10 mg, 25 mg, 50 mgPurity: 98%Clinical Data: No Development ReportedSize: 1

49、 mg, 5 mgwww.MedChemE 5 HYPERLINK https:/www.MedChemE/bcl-2-in-4.html Bcl-2-IN-4 HYPERLINK https:/www.MedChemE/bcl-2-in-4.html HYPERLINK https:/www.MedChemE/bcl-2-in-5.html Bcl-2-IN-5Cat. No.: HY-143872 Cat. No.: HY-143873Bcl-2-IN-4 is a potent, orally active andselective Bcl-2 inhibitor with an IC

50、of 1.5 nM.50Bcl-2-IN-4 displays 200-fold selectivity overBcl-xL (IC of 411 nM). Bcl-2-IN-4 inhibits RS4;5011 cell proliferation with an IC of 2.7 nM50(WO2021180040A1; compound 2).Bcl-2-IN-5 is a BCL-2 inhibitor with IC s of500.12 nM, 0.14 nM and 0.22 nM for Bcl-2 wild type,Bcl-2 D103Y and Bcl-2 G101

51、V, respectively.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/bcl-2-in-8.html Bcl-2-IN-8 HYPERLINK https:/www.MedChemE/bcl-2-in-8.html HYPERLINK https:/www.MedChemE/bcl-2-mcl-1-in-1.htm

52、l Bcl-2/Mcl-1-IN-1Cat. No.: HY-144819 Cat. No.: HY-144430Bcl-2-IN-8 is a potent anticancer agent.Bcl-2-IN-8 shows anti-proliferative activityagainst both drug-sensitive and drug-resistantcancer cells. Bcl-2-IN-8 induce apoptosis and cellcycle arrest at G1 phase. Bcl-2-IN-8 inhibits cellmigration in

53、a dose-dependent manner.Bcl-2/Mcl-1-IN-1 (compound 3) is a Bcl-2/Mcl-1inhibitor, with Ks of 1.19 M and 4.53 M foriMcl-1 and Bcl-2, respectively. Bcl-2/Mcl-1-IN-1can be used for the research of cancer.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98%Clinical Data: No Develo

54、pment ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/bcl-2-mcl-1-in-2.html Bcl-2/Mcl-1-IN-2 HYPERLINK https:/www.MedChemE/bcl-2-mcl-1-in-2.html HYPERLINK https:/www.MedChemE/bcl-2-mcl-1-in-3.html Bcl-2/Mcl-1-IN-3Cat. No.: HY-144428 Cat. No.: HY-144431Bcl-2/Mcl-1-IN-2 (compound 2) is a Bcl-2/

55、Mcl-1inhibitor, with Ks of 0.88 M and 4.70 M foriMcl-1 and Bcl-2, respectively. Bcl-2/Mcl-1-IN-2can be used for the research of cancer.Bcl-2/Mcl-1-IN-3 (compound 1) is a Bcl-2/Mcl-1inhibitor, with Ks of 0.14 M and 0.23 M foriMcl-1 and Bcl-2, respectively. Bcl-2/Mcl-1-IN-3can be used for the research

56、 of cancer.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/bcl-xl-antagonist-2.html Bcl-xL HYPERLINK https:/www.MedChemE/bcl-xl-antagonist-2.html HYPERLINK https:/www.MedChemE/bcl-xl-anta

57、gonist-2.html antagonist HYPERLINK https:/www.MedChemE/bcl-xl-antagonist-2.html HYPERLINK https:/www.MedChemE/bcl-xl-antagonist-2.html 2 HYPERLINK https:/www.MedChemE/bcl-xl-antagonist-2.html HYPERLINK https:/www.MedChemE/bcl2-in-1-1.html BCL2-IN-1Cat. No.: HY-12908 Cat. No.: HY-135273Bcl-xL antagon

58、ist 2 is a potent, selective, andorally active antagonist of BCL-XL with an IC50and K of 0.091 M and 65 nM, respectively. Bcl-xLiantagonist 2 promotes the apoptosis of cancercells.BCL2-IN-1 is a potent Bcl-2 inhibitor. BCL2-IN-1binds Bcl-2 with a K of 98%Clinical Data: No Development ReportedSize: 1

59、 mg, 5 mg HYPERLINK https:/www.MedChemE/bcl6-in-4.html BCL6-IN-4 HYPERLINK https:/www.MedChemE/bcl6-in-4.html HYPERLINK https:/www.MedChemE/bcl6-in-5.html BCL6-IN-5Cat. No.: HY-136640 Cat. No.: HY-136774BCL6-IN-4 is a potent B-cell lymphoma 6 (BCL6)inhibitor with an IC of 97 nM. BCL6-IN-4 has50anti-

60、tumor activities.BCL6-IN-5 is a potent BCL6 inhibitor exacted frompatent WO2018215801A1, example 1n, has a pIC of505.82.Purity: 98.44%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mgPurity: 99.82%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 5 mg, 1