7-epi-Taxol-7-epi-Paclitaxel-DataSheet-生命科學試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemE7-epi-TaxolCat. No.: HY-N0227CAS No.: 105454-04-4Synonyms: 7-epi-Paclitaxel分式: CHNO分量: 853.91作靶點: Microtubule/Tubulin作通路: Cell Cycle/DNA Damage; Cytoskeleton儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶

2、解性數(shù)據(jù)體外實驗 DMSO : 106.6 mg/mL (124.84 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 1.1711 mL 5.8554 mL 11.7108 mL5 mM 0.2342 mL 1.1711 mL 2.3422 mL10 mM 0.1171 mL 0.5855 mL 1.1711 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 7-ep

3、i-Taxoltaxol 的活性代謝物，在抑制細胞增殖及微管 (microtubule) 解離，誘導微管聚合等與 taxol作相當。IC50 & Target Microtubule/Tubulin 21/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE體外研究 7-epi-Taxol (7-Epitaxol) is a metabolite of taxol 1. 7-epi-Taxol has activity comparable to that of taxol on cellreplication, microtubule bundle

4、formation and in vitro microtubule polymerization 2. PLoS One. 2019 Jul 3;14(7):e0210377.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Royer I, et al. Paclitaxel metabolites in human plasma and urine: identification of 6 alpha-hydroxytaxol, 7-epitaxol and taxol hydrolysisprod

5、ucts using liquid chromatography/atmospheric-pressure chemical ionization mass spectrometry. Rapid Commun Mass Spectrom.1995;9(6):495-502.2. Ringel I, et al. Taxol is converted to 7-epitaxol, a biologically active isomer, in cell culture medium. J Pharmacol Exp Ther. 1987Aug;242(2):692-8.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021