Evenamide-NW-3509-DataSheet-生命科學(xué)試劑-MedChemExpresss

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEEvenamideCat. No.: HY-17612CAS No.: 1092977-61-1Synonyms: NW-3509分式: CHNO分量: 278.39作靶點(diǎn): Sodium Channel作通路: Membrane Transporter/Ion Channel儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 29

2、0 mg/mL (1041.70 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 3.5921 mL 17.9604 mL 35.9208 mL5 mM 0.7184 mL 3.5921 mL 7.1842 mL10 mM 0.3592 mL 1.7960 mL 3.5921 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。體內(nèi)實(shí)驗(yàn)請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥式選擇適當(dāng)?shù)娜芙獍?，配制前?qǐng)先配制澄的儲(chǔ)備液，再依次添加助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的作液，

3、建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的百分指該溶劑在您配制終溶液中的體積占)：1. 請(qǐng)依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.42 mg/mL (8.69 mM); Clear solution2. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.42 mg/mL (8.69 mM); Clear solution3. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% corn oil1/2 Mast

4、er of Small Molecules 您邊的抑制劑師www.MedChemESolubility: 2.42 mg/mL (8.69 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Evenamide (NW-3509)，種鈉通道 (sodium channel) 阻滯劑，在精神病，躁狂癥，抑郁和攻擊性的各種嚙齒動(dòng)物模型中具有顯著功效 1。IC50 & Target Sodium channel 1REFERENCES1. Valentina Zuliani, et al. Advances in Design and Development of Sodium Channel Blockers. Ion Channels and Their Inhibitors pp 79-115.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;F