歐盟藥品流通法規(guī)詳述(46張)課件

1、歐盟藥品流通法規(guī)詳述(46張)課件歐盟藥品流通法規(guī)詳述(46張)課件Guidelines on Good Distribution Practice of Medicinal Products for Human UseArticle 10 EU Dir 92/25/EEC人用藥品流通質(zhì)量管理指南 歐盟第92/25/EEC號(hào)法令第10款Personnel 人員Documentation 文件Premises and Equipment 房屋與設(shè)備Deliveries to Customers 向客戶交付Returns 退貨Self Inspections 自檢Guidelines on Goo

2、d DistributioEnsure products are authorised保證產(chǎn)品經(jīng)過(guò)批準(zhǔn)Storage conditions are observed (all times)關(guān)注產(chǎn)品儲(chǔ)存條件(任何時(shí)候)Prevent contamination from other products預(yù)防來(lái)自其它產(chǎn)品的污染Ensure adequate turnover of products保證足夠的產(chǎn)品流轉(zhuǎn)量Deliver right products 交付產(chǎn)品正確無(wú)誤Quality System Operated by Wholesalers should 批發(fā)商的質(zhì)量系統(tǒng)應(yīng)Ensure p

3、roducts are authorisedRight Address發(fā)貨地址正確Satisfactory Period發(fā)貨斯讓用戶滿意Provide tracing system for faulty products具備追蹤系統(tǒng)，追蹤有問(wèn)題的產(chǎn)品 Effective Recall Procedure有效的召回程序Quality System Operated by Wholesalers should 批發(fā)商的質(zhì)量系統(tǒng)Right AddressQuality System OpAppoint Management Representative - “Responsible Person”-

4、 each distribution centre每個(gè)分銷中心須指定-“負(fù)責(zé)人”-即管理代表Appropriately qualified 適當(dāng)?shù)馁Y質(zhì)Implement and maintain Quality System來(lái)實(shí)施與保持質(zhì)量系統(tǒng) Key Personnel 關(guān)鍵人員Appropriate ability and experience to guarantee products are properly handled有適當(dāng)?shù)哪芰εc經(jīng)驗(yàn)來(lái)保證產(chǎn)品正確處理Personnel 人員Appoint Management RepresentatTraining 培訓(xùn)Provide tra

5、ining for various GDP operations提供不同GDP操作的培訓(xùn)Training programmes培訓(xùn)計(jì)劃Maintain training records保存培訓(xùn)記錄Personnel 人員Training 培訓(xùn)Personnel 人Procedures 程序Written procedures should describe the different operations which may affect 應(yīng)當(dāng)有書(shū)面規(guī)程來(lái)描述不同的操作，它們可能影響：the quality of the products 產(chǎn)品質(zhì)量the distribution activi

6、ty 分銷活動(dòng)Procedures for 有以下規(guī)程：- Receipt and checking of deliveries 發(fā)送產(chǎn)品的接收/檢查- Storage 儲(chǔ)存Cleaning and maintenance of premises 貯存廠房的清潔與維護(hù)Documentation 文件Procedures 程序DocumentatioProcedures Contd 程序(續(xù))Recording of storage conditions 記錄儲(chǔ)存條件Security on site or in transit 現(xiàn)場(chǎng)或運(yùn)送安全Withdrawal from saleable st

7、ock 從銷售倉(cāng)庫(kù)撤回Records of - orders 記錄 -定單- returned products - 退貨Recall plans 召回計(jì)劃Procedures for various operations should be approved, signed and dated by the Responsible Person 各種規(guī)程均應(yīng)經(jīng)過(guò)負(fù)責(zé)人的批準(zhǔn)，簽字與簽發(fā)日期Documentation 文件Procedures Contd 程序(續(xù))DocRecords 記錄Made when each operation is taking place每次操作時(shí)均應(yīng)記錄Act

8、ivities and events are traceable 活動(dòng)/事件均可追蹤Readily available 方便查閱Retained for 5 years at least 至少保留5年Each purchase and sale 每次采購(gòu)與銷售有：Date 日期product/quantity 產(chǎn)品/數(shù)量name and address of supplier/consignee發(fā)貨企業(yè)/收貨人的名稱與地址Documentation 文件Records 記錄DocumentatioRecords Contd 記錄(續(xù)) Transactions between 以下交易的記錄：

9、 (i) Manufacturers and Wholesalers制造企業(yè)與批發(fā)企業(yè) (ii) Between Wholesalers 批發(fā)企業(yè)之間ensure traceability of origin/destination products i.e. Batch numbers to identify suppliers and those supplied with medicinal products能保證產(chǎn)品起點(diǎn)/終點(diǎn)的追蹤性，如用批號(hào)來(lái)識(shí)別供應(yīng)商及其發(fā)的藥品Documentation 文件Records Contd 記錄(續(xù))DocSuitable and adequate

10、to ensure proper conservation/ distribution 適用并足以保證貯存/分銷正確無(wú)誤Monitoring devices should be calibrated 監(jiān)控裝置應(yīng)當(dāng)進(jìn)行校準(zhǔn)Receiving 接收Receiving bays protect deliveries 有保護(hù)收貨的區(qū)域Receiving area separate from storage areas收貨區(qū)域與儲(chǔ)存區(qū)域分開(kāi)Deliveries examined on receipt 在收貨時(shí)檢查產(chǎn)品Damage 有無(wú)損壞corresponds to the order 與定單是否相符P

11、remises and Equipment庫(kù)房設(shè)施與設(shè)備Suitable and adequate to ensurStorage 儲(chǔ)存Medicinal products separate from other goods藥品與其它產(chǎn)品分開(kāi)Conditions specified - protect from light, moisture, below 25 規(guī)定條件-避光,防潮,低于25Temperature monitoring documented溫度監(jiān)測(cè)有記錄Records reviewed regularly 定期審核記錄Temperature Mapping. Storage

12、areas/cold rooms 溫度分布、儲(chǔ)存區(qū)/冷庫(kù)Premises and Equipment庫(kù)房設(shè)施與設(shè)備Storage 儲(chǔ)存Premises and EquiEnsure all locations within specific temperature range保證所有區(qū)域都在規(guī)定的溫度范圍內(nèi) 25oC 2 - 8oCPremises and Equipment庫(kù)房設(shè)施與設(shè)備Ensure all locations within spStorage Facility 儲(chǔ)存設(shè)施Clean 清潔Free from litter, dust, pests 無(wú)廢棄物、灰塵、蟲(chóng)害Free

13、from spillage or breakage 沒(méi)有溢出或損壞Microcontamination 微生物污染Cross contamination 交叉污染 Stock Rotation 庫(kù)存流轉(zhuǎn) “First in First out” Regular checks “先進(jìn)先出”定期檢查Premises and Equipment庫(kù)房設(shè)施與設(shè)備Storage Facility 儲(chǔ)存設(shè)施Premis Out of Date or Damaged Stock 將過(guò)期或損壞庫(kù)存 Quarantine 隔離/待檢 Destroy 銷毀Premises and Equipment庫(kù)房設(shè)施與設(shè)備P

14、remises and Equipment庫(kù)房設(shè)施與設(shè)Authorised Wholesalers 批準(zhǔn)的批發(fā)商Persons authorised to supply Medicinal Products經(jīng)批準(zhǔn)可從事藥品流通的人員IMB will look randomly at customer list愛(ài)爾蘭藥品管理局將在客戶清單中隨機(jī)抽查Supply Document 提供的文件應(yīng)有：Date 日期Name and Pharmaceutical Form 名稱與藥品劑型Quantity supplied 供應(yīng)數(shù)量Deliveries to Customers向客戶發(fā)貨Authorise

15、d Wholesalers 批準(zhǔn)的批Supplier and addressee 供應(yīng)商以及地址Name and address 名稱與地址Product Shelf Life 產(chǎn)品有效期Product dispatched must have a minimum defined shelf life remaining所發(fā)送的產(chǎn)品必須具有所規(guī)定最短有效期Deliveries to Customers向客戶發(fā)貨Supplier and addressee 供應(yīng)Transportation 運(yùn)輸Ensure that 保證：Identification is not lost 不丟失標(biāo)識(shí)Cros

16、s Contamination is avoided 避免交叉污染Products are secure 產(chǎn)品安全Breakage & theft are avoided 避免損壞與偷竊Protected from unacceptable environmental conditions 防止環(huán)境條件不符合要求Temperature is controlled during transport在運(yùn)輸中溫度受控Deliveries to Customers向客戶發(fā)貨Transportation 運(yùn)輸DelivCold Chain 冷鏈Products requiring refrigerati

17、on must be delivered in 需要冷凍產(chǎn)品必須在下列條件下發(fā)運(yùn)Refrigerated transport 冷凍運(yùn)輸Insulated boxes 絕熱箱Validate worst case situation during transport 驗(yàn)證在運(yùn)輸中最壞情況狀態(tài)Ensure product does not come in contact with ice packs 保證產(chǎn)品不接觸冰袋Responsible Person - ensure adequate delivery conditions maintained 負(fù)責(zé)人-保證保持足夠的交付條件Deliveri

18、es to Customers向客戶發(fā)貨Cold Chain 冷鏈DeliverControlled Drugs 受控藥物Maintain Security Chain 保持發(fā)貨各環(huán)節(jié)的安全Separate control drugs in deliveries to facilitate transfer受控藥品要采用單獨(dú)發(fā)送方式，方便移交Deliver direct to pharmacist at the hospital or retail outlet直接交到醫(yī)院或零售店的藥劑師Deliveries to Customers向客戶發(fā)貨Controlled Drugs 受控藥物DNon

19、 Defective Medicinal Products 無(wú)缺陷藥品Segregation from Saleable Stock until checked與銷售庫(kù)存相隔離，直到經(jīng)過(guò)檢查Products in good condition - original unwrapped containers產(chǎn)品保持良好狀態(tài) - 容器為原始包裝未經(jīng)開(kāi)封Products stored under proper conditions產(chǎn)品在正確條件下儲(chǔ)存Remaining shelf life acceptable仍有可接受的有效期Returns 退貨Non Defective Medicinal Pr

20、oducProducts examined and assessed by authorised, trained personnel產(chǎn)品由經(jīng)過(guò)批準(zhǔn)及培訓(xùn)人員的檢測(cè)與評(píng)估 Special storage conditions - time elapsed since issue特別儲(chǔ)存條件-自從發(fā)貨起的持續(xù)時(shí)間 Maintain records of returned goods保存退貨記錄 Return to stock operating FIFO System退回倉(cāng)庫(kù)，按先進(jìn)先出要求管理Returns 退貨Products examined and assessedProduct Dis

21、posal 產(chǎn)品處置Returned, Rejected or Recalled Products 退回，拒絕或召回產(chǎn)品Decision documented & recorded by Responsible Person決定文件與負(fù)責(zé)人的記錄Disposal in a timely manner以及時(shí)的方式處置Returns 退貨Product Disposal 產(chǎn)品處置Conduct and Record Self Inspections to monitor the implementation of and compliance with GDP Guidelines對(duì)執(zhí)行流通管理規(guī)

22、范情況進(jìn)行自檢并做好記錄：Self Inspection Procedure 自檢程序Inspection Reports 檢查報(bào)告Follow up Actions 跟蹤措施Inspection Log 檢查日志Self Inspection 自檢Conduct and Record Self InspecQuality Management 質(zhì)量管理No Quality System available 沒(méi)有質(zhì)量系統(tǒng)No System for Control of Documentation - Issue/Retrieval 無(wú)系統(tǒng)控制文件的發(fā)放/與收回Master copies SOP

23、S not approved by R. Person基準(zhǔn)SOP（原版）沒(méi)有經(jīng)過(guò)負(fù)責(zé)人批準(zhǔn)No Policy re.沒(méi)有以下相關(guān)的方針： Minimum acceptable product dating最短可接受產(chǎn)品有效期Return of refrigerated products 冷凍產(chǎn)品退貨GDP Deficiencies General 執(zhí)行流通規(guī)范常中的見(jiàn)缺陷Quality Management 質(zhì)量管Personnel 人員 Company training programme not available公司沒(méi)有培訓(xùn)計(jì)劃 No training SOP for GDP opera

24、tions沒(méi)有培訓(xùn)流通管理規(guī)范的SOP Personnel training not documented人員培訓(xùn)沒(méi)有記錄GDP Deficiencies General執(zhí)行流通規(guī)范常中的見(jiàn)缺陷Personnel 人員GDP DeficiDocumentation 文件Relevant SOPs not available in areas of operation 在操作區(qū)域沒(méi)有相關(guān)的SOPSOPs not available for 沒(méi)有下列SOP：Receipt and checking of deliveries對(duì)到貨的接收與檢查Warehouse cleaning/pest cont

25、rol倉(cāng)庫(kù)的清潔/蟲(chóng)害控制Temperature monitoring 溫度監(jiān)測(cè)Customer complaints 客戶投訴GDP Deficiencies General執(zhí)行流通規(guī)范常中的見(jiàn)缺陷Documentation 文件GDP DefCustomer complaints not closed out in a timely manner 沒(méi)有及時(shí)處理（了結(jié)）客戶的投訴 No customer complaint log maintained沒(méi)有保留客戶投訴記錄 Service/calibration reports not reviewed沒(méi)有審核校準(zhǔn)/ 維修報(bào)告 Pest co

26、ntrol reports not reviewed沒(méi)有經(jīng)過(guò)審核蟲(chóng)害控制報(bào)告 Calibration certs - acceptable error limit not specified 校準(zhǔn)證明-沒(méi)有具體規(guī)定誤差限度GDP Deficiencies General執(zhí)行流通規(guī)范常中的見(jiàn)缺陷Customer complaints not closedPremises and Equipment 庫(kù)房與設(shè)備Unauthorised products supplied 發(fā)了未批準(zhǔn)的產(chǎn)品Premises maintained in an untidy/dirty condition庫(kù)房處于骯亂狀態(tài)

27、Products not stored on pallets 產(chǎn)品沒(méi)有用托盤(pán)儲(chǔ)存Inadequate segregation receiving / picking/ dispatch areas 接收/檢料/發(fā)放區(qū)域沒(méi)有適當(dāng)隔離Out of date/short dated stock in inventory過(guò)期/短有效期產(chǎn)品沒(méi)有庫(kù)存清單GDP Deficiencies General執(zhí)行流通規(guī)范常中的見(jiàn)缺陷Premises and Equipment Temperature Mapping 溫度分布Not performed沒(méi)有進(jìn)行Product stored in close prox

28、imity to unit heaters產(chǎn)品近熱源儲(chǔ)存Temperature probes not calibrated溫度傳感器沒(méi)有經(jīng)過(guò)校準(zhǔn)GDP Deficiencies General執(zhí)行流通規(guī)范常中的見(jiàn)缺陷Temperature Mapping 溫度分布GDPremises and Equipment Contd 庫(kù)房與設(shè)備(續(xù))Temperature excursions in cold room not investigated 冷庫(kù)溫度超出范圍，沒(méi)做調(diào)查Data loggers not calibrated within operating range沒(méi)有對(duì)數(shù)據(jù)自動(dòng)記錄儀在其運(yùn)

29、行范圍內(nèi)對(duì)校準(zhǔn)MDA Drugs MDA藥品 Inadequate control. Poor security沒(méi)有足夠控制，安全性不良GDP Deficiencies General執(zhí)行流通規(guī)范常中的見(jiàn)缺陷Premises and Equipment Contd Discrepancies not adequately investigated對(duì)差異情況沒(méi)有適當(dāng)調(diào)查 Dangerous storage practices 儲(chǔ)存做法危險(xiǎn)： Rat poison stored over Baby Food Products將毒鼠藥儲(chǔ)存在嬰兒食品上 Organophosphorus compds

30、stored over open將有機(jī)磷化合物存放在上面 containers packaging components容器包裝成分。GDP Deficiencies General執(zhí)行流通規(guī)范常中的見(jiàn)缺陷GDP Deficiencies General執(zhí)行流Deliveries to Customers 向客戶發(fā)貨Cold storage units for delivery refrigerated products not validated發(fā)貨用冷藏產(chǎn)品的冷儲(chǔ)存單元沒(méi)有經(jīng)過(guò)驗(yàn)證Inadequate control re. ice packs沒(méi)有足夠控制，如冰袋Inadequate se

31、curity of MDA drugs對(duì)于MDA藥品沒(méi)有足夠的安全性 GDP Deficiencies General執(zhí)行流通規(guī)范常中的見(jiàn)缺陷Deliveries to Customers Returns 退貨 No SOP Re. return of product to saleable stock將退貨產(chǎn)品到銷售倉(cāng)庫(kù)無(wú)SOP Personnel not trained Re. checking returned goods沒(méi)有對(duì)人員進(jìn)行退回貨物檢查的培訓(xùn)GDP Deficiencies General執(zhí)行流通規(guī)范常中的見(jiàn)缺陷GDP Deficiencies General執(zhí)行流Self

32、Inspection 自檢No SOP defining Self Inspection沒(méi)有SOP來(lái)規(guī)定自檢Regular inspections not performed沒(méi)有進(jìn)行定期檢查Reports not issued 自檢無(wú)報(bào)告Follow up actions not documented 跟蹤措施無(wú)記錄Log of inspections not maintained沒(méi)有保存檢查記錄GDP Deficiencies General執(zhí)行流通規(guī)范常中的見(jiàn)缺陷Self Inspection 自檢GDP Current GDP Guideline 現(xiàn)行GDP指南Guidelines on

33、 GDP of Medicinal Products for HumanUse (94/C 63/03) 人用藥品流通管理規(guī)范(94/C 63/03)http:/ec.europa.eu/enterprise/pharmaceuticals/eudralex/homev4.htmsince 1994 從1994年開(kāi)始o(jì)ut dated 已過(guò)期limited scope, not detailed, no clear guidance范圍狹，不詳細(xì)，缺乏明確的指導(dǎo)性not reflecting current activities observed in wholesale distributi

34、on 不能反映現(xiàn)行藥品流通的相關(guān)活動(dòng)Developments new guidelines制訂-新的指南Current GDP Guideline Complex distribution networks where all players not wholesale distributors as defined in Directive 2001/83/EC在復(fù)雜的藥品流通網(wǎng)絡(luò)中的各種角色，并非都是 2001/83/EC號(hào)法令中定義的批發(fā)商This leads to inconsistencies in MS with respect to licensing and control o

35、f e.g. virtual wholesalers, outsourcing activities, brokers, transportation這在藥品銷售中，導(dǎo)致虛擬的批發(fā)商、外部采購(gòu)活動(dòng)、中間商、運(yùn)輸企業(yè)發(fā)放許可證及管理等方面的矛盾Why a new guideline?為什么要一個(gè)新指南?Complex distribution networks New legislative requirements arising from proposal from Commission (identification of GDP requirements and obligations

36、for brokers, verification of suppliers). These need to be incorporated into GDP Guidelines新立法要求來(lái)自委員會(huì)的提議(鑒別藥品流通的要求以及中間商，各供應(yīng)企業(yè)的義務(wù))，這需整合到GDP指南中Lack of harmonisation different procedures/formats at Community level and international level缺乏協(xié)調(diào)在歐盟層面與國(guó)際層面上有不同的程序/格式Why a new guideline?為什么要一個(gè)新指南?New legislati

37、ve requirements aComputerised systems 計(jì)算機(jī)化的系統(tǒng)Management of contract arrangements委托管理Transparency in supply chain 供應(yīng)鏈透明度Transportation 運(yùn)輸Counterfeit controls 假藥控制Likely new components可能的新的內(nèi)容Computerised systems 計(jì)算機(jī)化的系Subject all actors in distribution chain to conditions of wholesaling (except pharma

38、cies, retailers)取決于所有分銷鏈的參與者至批發(fā)商條件(除藥房，零售商外)More stringent verification of suppliers by wholesalers批發(fā)商對(duì)供貨商將會(huì)有更嚴(yán)格的檢查GDP Community database (EudraGDP)藥品流通歐盟數(shù)據(jù)庫(kù)Strengthen GDP compliance inspections: 強(qiáng)化藥品流通的達(dá)標(biāo)檢查:“Compilation of Community Procedures for GDP“歐盟將流通規(guī)程進(jìn)行匯編”P(pán)otential impacts 潛在影響Subject all a

39、ctors in distribuGDP Drafting Group Established 2008 (EMA)歐盟藥品管理局流通規(guī)范起草小組于2008年成立Concept Paper on revision published February 2009修訂的概念文件已于2009年2月公布Deadline for Comments May 2009征求意見(jiàn)截止日期2009年5月Guideline on GDP 藥品流通指南well advanced 相當(dāng)先進(jìn)Work in progress 工作進(jìn)展GDP Drafting Group Establishedharmonised with

40、 WHO Guideline與WHO指南相協(xié)調(diào)/一致draft for public consultation expected Q2 2010預(yù)期在2010年第2季度發(fā)布草案進(jìn)行磋商some clarifications / definitions pending有一些定義/需澄清的問(wèn)題待定must await EU Directive 必須等候歐盟的法令Layout of Guideline expected to mirror GMPs預(yù)計(jì)指南的大體結(jié)構(gòu)參照GMP的形式Work in progress 工作進(jìn)展harmonised with WHO GuidelineWProcedure

41、s on 這類程序包括：Inspection process 檢查程序Issue of GDP Certificate 簽發(fā)藥品流通規(guī)范GDP證書(shū)Serious GDP non-compliance 嚴(yán)重違反藥品流通規(guī)范Training and qualification of Inspectors檢查員的培訓(xùn)與資質(zhì)確認(rèn)Wholesale Distribution Authorisation format批發(fā)商許可批準(zhǔn)格式文件GDP Inspection report format 藥品流通規(guī)范檢查報(bào)告格式Likely amendment of Compilation of Community

42、 Procedures 可能修訂歐盟程序匯編Procedures on 這類程序包括：LikeObligations for wholesalers distributing to third countries (import for export)批發(fā)商對(duì)第三國(guó)的義務(wù)(進(jìn)口用于出口)Inspection process for brokers檢查中間商的程序EudraGDP format Eudra藥品流通格式文件GDP Certificates format 藥品流通證書(shū)格式Non-conformance certificates 不達(dá)標(biāo)證書(shū)Future developments 前景

43、Obligations for wholesalers diImpact on Wholesalers 影響到批發(fā)商N(yùn)ew detailed GDP Guidelines 有新的詳細(xì)的藥品流通指南New chapters (Quality Risk Management, Validation of Computerised Systems, Deviations, Change Control)會(huì)有一些新的章節(jié)(質(zhì)量風(fēng)險(xiǎn)管理，計(jì)算機(jī)化系統(tǒng)驗(yàn)證，偏差，變更控制)New format of Wholesalers Authorisation批準(zhǔn)新批發(fā)商許可的格式GDP Certificate a

44、fter each inspection每次檢查發(fā)GDP證書(shū)Information uploaded onto EudraGDP信息上傳到 EudraGDP（歐盟藥品流通數(shù)據(jù)庫(kù)）Future developments 前景Impact on Wholesalers 影響到批1、有時(shí)候，我們活得累，并非生活過(guò)于刻薄，而是我們太容易被外界的氛圍所感染，被他人的情緒所左右。2、身材不好就去鍛煉，沒(méi)錢就努力去賺。別把窘境遷怒于別人，唯一可以抱怨的，只是不夠努力的自己。3、大概是沒(méi)有了當(dāng)初那種毫無(wú)顧慮的勇氣，才變成現(xiàn)在所謂成熟穩(wěn)重的樣子。4、世界上只有想不通的人，沒(méi)有走不通的路。將帥的堅(jiān)強(qiáng)意志，就像城市

45、主要街道匯集點(diǎn)上的方尖碑一樣，在軍事藝術(shù)中占有十分突出的地位。5、世上最美好的事是：我已經(jīng)長(zhǎng)大，父母還未老;我有能力報(bào)答，父母仍然健康。6、沒(méi)什么可怕的，大家都一樣，在試探中不斷前行。7、時(shí)間就像一張網(wǎng)，你撒在哪里，你的收獲就在哪里。紐扣第一顆就扣錯(cuò)了，可你扣到最后一顆才發(fā)現(xiàn)。有些事一開(kāi)始就是錯(cuò)的，可只有到最后才不得不承認(rèn)。8、世上的事，只要肯用心去學(xué)，沒(méi)有一件是太晚的。要始終保持敬畏之心，對(duì)陽(yáng)光，對(duì)美，對(duì)痛楚。9、別再去抱怨身邊人善變，多懂一些道理，明白一些事理，畢竟每個(gè)人都是越活越現(xiàn)實(shí)。10、山有封頂，還有彼岸，慢慢長(zhǎng)途，終有回轉(zhuǎn)，余味苦澀，終有回甘。11、人生就像是一個(gè)馬爾可夫鏈，你的未

46、來(lái)取決于你當(dāng)下正在做的事，而無(wú)關(guān)于過(guò)去做完的事。12、女人，要么有美貌，要么有智慧，如果兩者你都不占絕對(duì)優(yōu)勢(shì)，那你就選擇善良。13、時(shí)間，抓住了就是黃金，虛度了就是流水。理想，努力了才叫夢(mèng)想，放棄了那只是妄想。努力，雖然未必會(huì)收獲，但放棄，就一定一無(wú)所獲。14、一個(gè)人的知識(shí)，通過(guò)學(xué)習(xí)可以得到;一個(gè)人的成長(zhǎng)，就必須通過(guò)磨練。若是自己沒(méi)有盡力，就沒(méi)有資格批評(píng)別人不用心。開(kāi)口抱怨很容易，但是閉嘴努力的人更加值得尊敬。15、如果沒(méi)有人為你遮風(fēng)擋雨，那就學(xué)會(huì)自己披荊斬棘，面對(duì)一切，用倔強(qiáng)的驕傲，活出無(wú)人能及的精彩。16、成功的秘訣在于永不改變既定的目標(biāo)。若不給自己設(shè)限，則人生中就沒(méi)有限制你發(fā)揮的藩籬。幸

47、福不會(huì)遺漏任何人，遲早有一天它會(huì)找到你。17、一個(gè)人只要強(qiáng)烈地堅(jiān)持不懈地追求，他就能達(dá)到目的。你在希望中享受到的樂(lè)趣，比將來(lái)實(shí)際享受的樂(lè)趣要大得多。18、無(wú)論是對(duì)事還是對(duì)人，我們只需要做好自己的本分，不與過(guò)多人建立親密的關(guān)系，也不要因?yàn)殛P(guān)系親密便掏心掏肺，切莫交淺言深，應(yīng)適可而止。19、大家常說(shuō)一句話，認(rèn)真你就輸了，可是不認(rèn)真的話，這輩子你就廢了，自己的人生都不認(rèn)真面對(duì)的話，那誰(shuí)要認(rèn)真對(duì)待你。20、沒(méi)有收拾殘局的能力，就別放縱善變的情緒。1、不是井里沒(méi)有水，而是你挖的不夠深。不是成功來(lái)得慢，而是你努力的不夠多。2、孤單一人的時(shí)間使自己變得優(yōu)秀，給來(lái)的人一個(gè)驚喜，也給自己一個(gè)好的交代。3、命運(yùn)給

48、你一個(gè)比別人低的起點(diǎn)是想告訴你，讓你用你的一生去奮斗出一個(gè)絕地反擊的故事，所以有什么理由不努力!4、心中沒(méi)有過(guò)分的貪求，自然苦就少?？诶锊徽f(shuō)多余的話，自然禍就少。腹內(nèi)的食物能減少，自然病就少。思緒中沒(méi)有過(guò)分欲，自然憂就少。大悲是無(wú)淚的，同樣大悟無(wú)言。緣來(lái)盡量要惜，緣盡就放。人生本來(lái)就空，對(duì)人家笑笑，對(duì)自己笑笑，笑著看天下，看日出日落，花謝花開(kāi)，豈不自在，哪里來(lái)的塵埃!5、心情就像衣服，臟了就拿去洗洗，曬曬，陽(yáng)光自然就會(huì)蔓延開(kāi)來(lái)。陽(yáng)光那么好，何必自尋煩惱，過(guò)好每一個(gè)當(dāng)下，一萬(wàn)個(gè)美麗的未來(lái)抵不過(guò)一個(gè)溫暖的現(xiàn)在。6、無(wú)論你正遭遇著什么，你都要從落魄中站起來(lái)重振旗鼓，要繼續(xù)保持熱忱，要繼續(xù)保持微笑，就

49、像從未受傷過(guò)一樣。7、生命的美麗，永遠(yuǎn)展現(xiàn)在她的進(jìn)取之中;就像大樹(shù)的美麗，是展現(xiàn)在它負(fù)勢(shì)向上高聳入云的蓬勃生機(jī)中;像雄鷹的美麗，是展現(xiàn)在它搏風(fēng)擊雨如蒼天之魂的翱翔中;像江河的美麗，是展現(xiàn)在它波濤洶涌一瀉千里的奔流中。8、有些事，不可避免地發(fā)生，陰晴圓缺皆有規(guī)律，我們只能坦然地接受;有些事，只要你愿意努力，矢志不渝地付出，就能慢慢改變它的軌跡。9、與其埋怨世界，不如改變自己。管好自己的心，做好自己的事，比什么都強(qiáng)。人生無(wú)完美，曲折亦風(fēng)景。別把失去看得過(guò)重，放棄是另一種擁有;不要經(jīng)常艷羨他人，人做到了，心悟到了，相信屬于你的風(fēng)景就在下一個(gè)拐彎處。10、有些事想開(kāi)了，你就會(huì)明白，在世上，你就是你，你

50、痛痛你自己，你累累你自己，就算有人同情你，那又怎樣，最后收拾殘局的還是要靠你自己。11、人生的某些障礙，你是逃不掉的。與其費(fèi)盡周折繞過(guò)去，不如勇敢地攀登，或許這會(huì)鑄就你人生的高點(diǎn)。12、有些壓力總是得自己扛過(guò)去，說(shuō)出來(lái)就成了充滿負(fù)能量的抱怨。尋求安慰也無(wú)濟(jì)于事，還徒增了別人的煩惱。13、認(rèn)識(shí)到我們的所見(jiàn)所聞都是假象，認(rèn)識(shí)到此生都是虛幻，我們才能真正認(rèn)識(shí)到佛法的真相。錢多了會(huì)壓死你，你承受得了嗎?帶，帶不走，放，放不下。時(shí)時(shí)刻刻發(fā)悲心，饒益眾生為他人。14、夢(mèng)想總是跑在我的前面。努力追尋它們，為了那一瞬間的同步，這就是動(dòng)人的生命奇跡。15、懶惰不會(huì)讓你一下子跌倒，但會(huì)在不知不覺(jué)中減少你的收獲;勤

51、奮也不會(huì)讓你一夜成功，但會(huì)在不知不覺(jué)中積累你的成果。人生需要挑戰(zhàn)，更需要堅(jiān)持和勤奮!16、人生在世：可以缺錢，但不能缺德;可以失言，但不能失信;可以倒下，但不能跪下;可以求名，但不能盜名;可以低落，但不能墮落;可以放松，但不能放縱;可以虛榮，但不能虛偽;可以平凡，但不能平庸;可以浪漫，但不能浪蕩;可以生氣，但不能生事。17、人生沒(méi)有筆直路，當(dāng)你感到迷茫、失落時(shí)，找?guī)撞窟@種充滿正能量的電影，坐下來(lái)靜靜欣賞，去發(fā)現(xiàn)生命中真正重要的東西。18、在人生的舞臺(tái)上，當(dāng)有人愿意在臺(tái)下陪你度過(guò)無(wú)數(shù)個(gè)沒(méi)有未來(lái)的夜時(shí)，你就更想展現(xiàn)精彩絕倫的自己。但愿每個(gè)被努力支撐的靈魂能吸引更多的人同行。19、積極的人在每一次憂患中都看到一個(gè)機(jī)會(huì)，而消極的人則在每個(gè)機(jī)會(huì)中看到了某種憂患。莫找借口失敗，只找理由成功。20、每一個(gè)成就和長(zhǎng)進(jìn)，都蘊(yùn)含著曾經(jīng)受過(guò)的寂寞、灑過(guò)的汗水、流過(guò)的眼淚。許多時(shí)候不是看到希望才去堅(jiān)持，而