Oxindole-Indolin-2-one-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEOxindoleCat. No.: HY-Y0061CAS No.: 59-48-3Synonyms: Indolin-2-one分式: CHNO分量: 133.15作靶點(diǎn): Others作通路: Others儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 100 mg/mL (751.03 mM; Need ultrasoni

2、c)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 7.5103 mL 37.5516 mL 75.1033 mL5 mM 1.5021 mL 7.5103 mL 15.0207 mL10 mM 0.7510 mL 3.7552 mL 7.5103 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。體內(nèi)實(shí)驗(yàn)請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥式選擇適當(dāng)?shù)娜芙獍?，配制前?qǐng)先配制澄清的儲(chǔ)備液，再依次添加助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下

3、溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請(qǐng)依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (18.78 mM); Clear solution2. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (18.78 mM); Clear solution3. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% corn oil1/2 Master of Small Molecules 您邊的抑制劑師ww

4、w.MedChemESolubility: 2.5 mg/mL (18.78 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Oxindole (Indolin-2-one)芳族雜環(huán)砌塊。 Oxindole衍物已成為激酶抑制劑研究中的主要化合物。體外研究 Oxindole (Indolin-2-one) is a bicyclic structure consisting of a benzene ring fused to 2-pyrrolidone.Substituted indolinones can be referred as privileged

5、 structures owing to their excellent binding affinity formany receptors and to the number of approved drugs containing this scaffold 1. Oxindole has been found intissues and fluids of mammals as well as natural products produced by a range of plants, bacteria andinvertebrates. 2-indolinone derivativ

6、es possess diverse range of pharmacological activities including anti-cancer, anti-HIV, anti-diabetic, antibacterial, antioxidant, kinase inhibitory, AChE inhibitory, anti-leishmanial,b3 adrenergic receptor agonistic, phosphatase inhibitory, analgesic, spermicidal, vasopressin antagonists,progestero

7、ne antagonists, neuroprotection, NMDA blocker and sleep inducing activities 2.REFERENCES1. Leoni A, et al. 2-Indolinone a versatile scaffold for treatment of cancer: a patent review (2008-2014). Expert Opin Ther Pat.2016;26(2):149-73.2. Kaur M, et al. Oxindole: A chemical prism carrying plethora of therapeutic benefits. Eur J Med Chem. 2016 Nov 10;123:858-894.McePdfHeightCaution: Product has not been fully validated for medical applications.For researc