心血管文獻(xiàn)閱讀報(bào)告

心血管文獻(xiàn)閱讀報(bào)告Half-CenturyofProgressinHealth:TheNationalAcademyofMedicineat50半個(gè)世紀(jì)的健康進(jìn)步:50歲的國家醫(yī)學(xué)研究院ConqueringAtheroscleroticCardiovascularDisease—50YearsofProgress征服動(dòng)脈粥樣硬化性心血管疾病-50GarH.Gibbons,M.D.,ChristineE.Seidman,M.D.,andEricJ.Topol,M.D翻譯：貓，校對(duì)：叮當(dāng)丸子麻Thetrajectory發(fā)展軌跡ofcardiovasculardiseaseisshapedbytheinteractionbetweenpolygenicfactorsandenvironmentalinfluences.Longitudinalstudies縱向研究haveprovidedevidencethatduringchildhoodandearlyadulthood,exposuretoneighborhood-levelfactorssuchassocialdeprivation社會(huì)剝奪andracialsegregation種族隔離,limitedaccesstoahealthydiet,lackofopportunitiesforregularexercise,andsuboptimal次選的healthcarecanaffectthetrajectoryofcardiovasculardiseaseoverthelifecourse.Theinfluenceofsocialdeterminantsofhealthandtheexacerbationofhealthinequitieshavepreventedfurtherprogressagainstcardiovasculardisease.Addressinginequitieswillbeanimportantnextstepineffortstoalleviatetheburdensofcardiovasculardisease.Thisstepwillrequireacollectiveapproachinvolvingacademicresearchers,clinicians,andmanyotherpartnersthatengagesthecommunitytoteststrategiesforachievingoptimaluptakeandcontinuedsustainabilityofproveninterventions?心血管疾病的發(fā)展軌跡是由多基因因素和環(huán)境影響的相互作用形成的。縱向研究提供證據(jù)表明,在兒童和成年早期,暴露在社區(qū)水平因素如社會(huì)剝奪和種族隔離,缺乏健康飲食,缺乏定期鍛煉的機(jī)會(huì),和次優(yōu)醫(yī)療會(huì)影響心血管疾病在生命歷程的軌跡。健康的社會(huì)決定因素的影響和健康不平等的加劇阻礙了在防治心血管疾病方面取得進(jìn)一步進(jìn)展。解決不平等問題將是努力減輕心血管疾病負(fù)擔(dān)的下一步重要步驟。這一步驟將需要一個(gè)包括學(xué)術(shù)研究人員、臨床醫(yī)生和許多其他合作伙伴在內(nèi)的集體方法，這些合作伙伴參與社區(qū)，以測試策略，以實(shí)現(xiàn)已證實(shí)的干預(yù)措施的最佳吸收和持續(xù)可持續(xù)性。Asbiomedicineenterstheageofprecisionhealth,weanticipatethatgenomicsciencewillcontinuetoexpandourunderstandingofthebiologicsystemsandmolecularnetworksthatmediatethedevelopmentandclinicalmanifestationofcardiovasculardisease.Newmethodsofimmunephenotypingand“multiomic”characterizationoftheepigenome,transcriptome,metabolome,andmicrobiomewillprobablyacceleratethediscoveryofbiomarkers生物標(biāo)記物andtheidentificationofnewtargets靶點(diǎn)fortherapeuticintervention治療干預(yù).Wealsoexpectthatinvestigatorswilladvanceourunderstandingofthewaysinwhichthesocialdeterminantsofhealth“getundertheskin”tomodulatetheepigenomeandotherbiologicsystemstopromoteresilienceoracceleratediseasedevelopment.Welookforwardtothedevelopmentofbiomarkers,personalsensortechnology個(gè)人傳感器技術(shù),andartificial-intelligenceapps人工智能應(yīng)用程序thatwillcontinuouslymonitorbiologicsystems,permitreal-timeimplementationofpersonalizeddietaryrecommendations個(gè)性化飲食建議,andreinforcetheimportanceofhealthylifestylehabits健康生活方式forthepreventionofcardiovasculardisease.隨著生物醫(yī)學(xué)進(jìn)入精準(zhǔn)健康時(shí)代，我們預(yù)計(jì)基因組科學(xué)將繼續(xù)擴(kuò)大我們對(duì)介導(dǎo)心血管疾病發(fā)展和臨床表現(xiàn)的生物系統(tǒng)和分子網(wǎng)絡(luò)的理解。免疫表型的新方法和表觀基因組、轉(zhuǎn)錄組、代謝組和微生物組的“多組學(xué)”表征可能會(huì)加速生物標(biāo)志物的發(fā)現(xiàn)和治療干預(yù)的新靶點(diǎn)的確定。我們也希望研究人員能夠加深