alpha-Hederin-α-Hederin-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEalpha-HederinCat.No.:HY-N0255CASNo.:27013-91-8Synonyms:α-Hederin分?式:C??H??O??分?量:750.96作?靶點:Apoptosis作?通路:Apoptosis儲存?式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實驗DMSO:≥100mg/mL(133.16mM)H2O:<0.1mg/mL(insoluble)*"≥"meanssoluble,butsaturationunknown.MassSolvent1mg5mg10mgConcentration制備儲備液1mM1.3316mL6.6581mL13.3163mL5mM0.2663mL1.3316mL2.6633mL10mM0.1332mL0.6658mL1.3316mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；?旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲備液的保存?式和期限：-80°C,6months;-20°C,1month。-80°C儲存時，請在6個?內(nèi)使?，-20°C儲存時，請在1個?內(nèi)使?。體內(nèi)實驗請根據(jù)您的實驗動物和給藥?式選擇適當?shù)娜芙?案。以下溶解?案都請先按照InVitro?式配制澄的儲備液，再依次添加助溶劑：(為保證實驗結(jié)果的可靠性，澄的儲備液可以根據(jù)儲存條件，適當保存；體內(nèi)實驗的?作液，建議您現(xiàn)?現(xiàn)配，當天使?；以下溶劑前顯?的百分?指該溶劑在您配制終溶液中的體積占?；如在配制過程中出現(xiàn)沉淀1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemE、析出現(xiàn)象，可以通過加熱和/或超聲的?式助溶)1.請依序添加每種溶劑：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥2.5mg/mL(3.33mM);Clearsolution2.請依序添加每種溶劑：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥2.5mg/mL(3.33mM);Clearsolution3.請依序添加每種溶劑：10%DMSO>>90%cornoilSolubility:≥2.5mg/mL(3.33mM);ClearsolutionBIOLOGICALACTIVITY?物活性alpha-Hederin(α-Hederin)?種單橋糖三萜皂苷，對多種腫瘤細胞具有良好的抗腫瘤作?。alpha-Hederin可通過激活線粒體依賴性途徑抑制胃癌細胞增殖，誘導(dǎo)凋亡(apoptosis)，并伴有?胱?肽減少和活性氧?成。體外研究alpha-Hederin(α-Hederin)iscytotoxicandinhibitsproliferationinbothcellinesatratherlowconcentrations.alpha-Hederin(α-Hederin)reducesthemitoticactivityintreatedcells[2].體內(nèi)研究alpha-Hederin(α-Hederin)haspreventiveeffectonsensitizedratslikethymoquinone.ItmayinterveneinmiRNA-126expression,whichconsequentlycouldinterferewithIL-13secretionpathwayleadingtoareductionininflammatoryresponses[3].REFERENCES[1].DanloySetal.Effectsofalpha-hederin,asaponinextractedfromHederahelix,oncellsculturedinvitro.PlantaMed,1994Feb,60(1):45-9.[2].MaryamFallahietal.EffectofAlpha-Hederin,theactiveconstituentofNigellasativa,onmiRNA-126,IL-13mRNAlevelsandinflammationoflungsinovalbumin-sensitizedmalerats.PlantaMed,1994Feb,60(1):45-9.[3].WangJ,etal.α-Hederininducestheapoptosisofgastriccancercellsaccompaniedbyglutathionedecrementandreactiveoxygenspeciesgenerationviaactivatingmitochondrialdependentpathway.PhytotherRes.2020;34(3):601-611.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forre