Efflux-inhibitor-1-DataSheet-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEEffluxinhibitor-1Cat.No.:HY-112505CASNo.:1776055-29-8分?式:C??H??N?O?分?量:479.53作?靶點:BCRP作?通路:MembraneTransporter/IonChannel儲存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.溶解性數(shù)據(jù)體外實驗DMSO:50mg/mL(104.27mM;ultrasonicandwarmingandheatto60°C)MassSolvent1mg5mg10mgConcentration制備儲備液1mM2.0854mL10.4269mL20.8538mL5mM0.4171mL2.0854mL4.1708mL10mM0.2085mL1.0427mL2.0854mL體內(nèi)實驗請根據(jù)您的實驗動物和給藥?式選擇適當?shù)娜芙?案。以下溶解?案都請先按照InVitro?式配制澄的儲備液，再依次添加助溶劑：(為保證實驗結(jié)果的可靠性，澄的儲備液可以根據(jù)儲存條件，適當保存；體內(nèi)實驗的?作液，建議您現(xiàn)?現(xiàn)配，當天使?；以下溶劑前顯?的百分?指該溶劑在您配制終溶液中的體積占?；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的?式助溶)1.請依序添加每種溶劑：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥2.5mg/mL(5.21mM);Clearsolution2.請依序添加每種溶劑：10%DMSO>>90%cornoilSolubility:≥2.5mg/mL(5.21mM);ClearsolutionBIOLOGICALACTIVITY1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemE?物活性Effluxinhibitor-1(compound2)吡唑啉[1,5-a]嘧啶外排抑制劑。Effluxinhibitor-1在ABCG2/BCRP，ABCB1間選擇性靶向ABCG2，IC50分別為0.45μM和2.17μM。IC50&TargetIC50:0.45μM(ABCG2/BCRP),2.17μM(ABCB1)[1]REFERENCES[1].Larson,etal.Selectiveeffluxinhibitorsandrelatedpharmaceuticalcompositionsandmethodsoftreatment:UnitedStates,US9056111[P].2015-06-16.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax:0