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HISTOLOGY&

EMBRYOLOGY

MaleandFemale

ReproductiveSystems7/24/20231ppt課件7/24/20232ppt課件ReproductiveSystemSex,

Gender,

ReproductionGermCells:spermandovum(haploid)SexHormones:

Male---Androgens(Testosterone)

Female---Estrogen,ProgestogenDevelopmentalStages:infant,child,puberty,adult,menopauseandold

7/24/20233ppt課件7/24/20234ppt課件7/24/20235ppt課件7/24/20236ppt課件MaleReproductiveSystemTestis:

producingspermandhormoneEpididymis:

spermmaturation,storageVasdeferens:

spermpassageduringejaculationAccessoryglands(prostate,seminalvesicle,bulbourethralgland):seminalplasma---environmentforspermsPenisandscrotum7/24/20237ppt課件7/24/20238ppt課件7/24/20239ppt課件7/24/202310ppt課件TESTIS

apairinscrotumCapsule:

tunicavaginalis,albugineaandvasculosa,mediastinumtestis&septulum

testisinto250testicularlobulesSeminiferousTubuleproducingspermTesticularInterstitiumproducingandrogensbyLeydigcell7/24/202311ppt課件7/24/202312ppt課件SeminiferousTubulesSpermatogenicCells

-spermatogonia

-primaryspermatocyte

-secondaryspermatocyte

-spermatid

-testicularspermSertoliCell7/24/202313ppt課件7/24/202314ppt課件SpermatogenesisStage1:spermatogoniamitosis(5)Stage2:spermatocytemeiosis(2)Stage3:spermiogenesis

-roundspermatid

-elongatedspermatid

-testicularsperm

(nomotility,nofertilizingcapability)7/24/202315ppt課件7/24/202316ppt課件7/24/202317ppt課件SPERMCondensednucleuswithhaploid(X/Y)FlagellumandmitochondrialsheathAcrosomecontainingenzymesMembranewithovum-recognizingligand7/24/202318ppt課件7/24/202319ppt課件SertoliCellSupportandnutritionBlood-testisBarrierSecretion:AndrogenBindingProtein

InhibinPhagocytosis7/24/202320ppt課件7/24/202321ppt課件7/24/202322ppt課件LeydigCellinInterstitiumSteroid-producingcellstructureAndrogens:spermatogenesis/secondarysexualcharacteristicdevelopmentHormonalregulation

-HypothalamusGnRH

-PituitaryGlandFSHLH(ICSH)

-TestisSertoliLeydig7/24/202323ppt課件7/24/202324ppt課件7/24/202325ppt課件SpermPassageTubulesrectusRetetestisEfferentductulesDuctusepididymisVasdeferensUrethra7/24/202326ppt課件EpididymisEfferentductules:principalcellwithcilia&glandularcellDuctusepididymis:pseudostratifiedcolumnarcellwithsterociliaMicroenvironmentforspermmaturation-motility-fertilizingcapability7/24/202327ppt課件7/24/202328ppt課件7/24/202329ppt課件7/24/202330ppt課件7/24/202331ppt課件Semen

sperm+seminalplasmaSpermcount,motilityandmorphologySeminalplasma(pH7.4,2-6ml)-bulbourethralgland:lubricate-prostate:ACP,Enzymes,PSP-seminalvesicle:fructose,decapacitationfactor,coagulationfactor7/24/202332ppt課件FemaleReproductiveSystem

MenstrualCycle(bleedingmonthly)andsignificantdevelopmentalstagesOvumproductionEstrogen/progestogensecretionEmbryodevelopmentFetalbreast-feeding7/24/202333ppt課件7/24/202334ppt課件FemaleReproductiveSystemOvaryproducingovum&hormonesOviductUterusVaginaMammarygland7/24/202335ppt課件OvarianFollicleDevelopmentPrimordialfollicleprimaryoocyte+flatfollicularcells(1millionatbirth,40,000beforepuberty)GrowingFollicles(fewdecades/month)-primary-secondary

MatureFollicle(onepermonth,secondaryoocyte)AtresicFollicle7/24/202336ppt課件7/24/202337ppt課件7/24/202338ppt課件7/24/202339ppt課件GrowingFolliclesPrimary:-primaryoocytegrowing-follicularcellproliferation-zonapellucidaformationSecondary:-follicularantrum-cumulusoophorus&coronaradiata-stratumgranulosum-thecainternaandthecaexterna7/24/202340ppt課件EstrogenProductionLH:17@hydroxydaseinthecacell(cholesterol-----androgen)AndrogendiffuseintogranularcellFSH:aromataseingranularcell(androgen-----estrogen)7/24/202341ppt課件7/24/202342ppt課件7/24/202343ppt課件OvulationOncepermonthon14dayofthecycle36–48hbeforeovulation,primaryfolliclecompletesfirstmeiosis,becomingsecondaryoocyteandfirstpolarbodyLHsurgeleadingtoovulationdeliveringsecondaryoocyteandz.p/c.r-nofertilization:degeneration-fertilization:completingsecondmeiosis7/24/202344ppt課件7/24/202345ppt課件7/24/202346ppt課件CorpusLuteumGranulosaluteincellproducingprogestogenThecaluteincellproducingestrogenwithgranulosaluteincellCorpusluteumofmenstruation(14days,thendegeneration,corpusalbicans)Corpusluteumofpregnancyproducingestrogen/progestogen/relaxinunderhCG7/24/202347ppt課件7/24/202348ppt課件HOMEWORKWhatisthemaindifferencesbetweenspermatogenesisandoogenesis?Describethestructureofovaryat6yrand25yr;7thdayofthecycle,21stdayofthecycle,onemonthafterpregnancyHowmanytypesofcellinovaryinvolveinhormoneproduction?

7/24/202349ppt課件7/24/202350ppt課件OVIDUCT

Infundibulum,ampulla,isthmusandintramuralportionMucosalfoldswithsimplecolumnarciliatedcellsandsecretorycellsInnercircularandouterlongitudinalsmoothmusclecoatOutercoveringofperitonealmesothelium7/24/202351ppt課件7/24/202352ppt課件UTERUSUterusbody-perimetrium-myometriumendometrium:basallayerandfunctionallayers(menstrualcycle)UterusCervixNomenstrualcycleinendocervix7/24/202353ppt課件7/24/202354ppt課件MenstrualCycle(28days)1-4day:menstrualphase5-14day:proliferative(follicularphase)15-28day:secretory(lutealphase)thick,uterinegland,stromacell,matrix,spiralartery,predecidualcell,ovarystructure&hormoneprofile7/24/202355ppt課件7/24/202356

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