Diprotin-A-TFA-Ile-Pro-Pro-TFA-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEDiprotin A TFACat. No.: HY-111174ACAS No.: 209248-71-5Synonyms: Ile-Pro-Pro (TFA)分式: CHFNO分量: 455.47作靶點(diǎn): Dipeptidyl Peptidase作通路: Metabolic Enzyme/Protease儲存式: Powder -20C 3 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) H2O

2、 : 77.5 mg/mL (170.15 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 2.1955 mL 10.9777 mL 21.9553 mL5 mM 0.4391 mL 2.1955 mL 4.3911 mL10 mM 0.2196 mL 1.0978 mL 2.1955 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Diprotin A (TFA)肽

3、基肽酶 IV (DPP-IV) 的抑制劑。IC50 & Target DPP-IV 1.體外研究Diprotin A increases the phosphorylation of Src and vascular endothelial-cadherin (VE-cadherin) in humanendothelial cells and disrupts endothelial cell-to-cell junctions, which are attenuated by CXCR4 (receptor of1/2 Master of Small Molecules 您邊的抑制劑師ww

4、w.MedChemESDF-1)-blocker or Src-inhibitor 1.體內(nèi)研究 In the model of retinopathy of prematurity, Diprotin A increases not only retinal vascularity but also leakage.Additionally, in the murine diabetic retinopathy model, Diprotin A increases the phosphorylation of Src andVE-cadherin and aggravates vascul

5、ar leakage in the retinas. Collectively, Diprotin A induces vascularleakage by augmenting the SDF-1/CXCR4/Src/VE-cadherin signaling pathway 1.REFERENCES1. Lee CS, et al. Dipeptidyl Peptidase-4 Inhibitor Increases Vascular Leakage in Retina through VE-cadherin Phosphorylation. Sci Rep.2016 Jul 6;6:29393.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021