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1、Typical CT and MRI signs of hepatic epithelioid hemangioendothelioma,hi,mndiuendu,i:lium,epi:ld,hptk,1,.,All cases were classified as one of three types: (i) Solitary nodular type ; (ii) multifocal nodular type ; or (iii) diffuse type . The diameter of the lesions ranged from 5 to 105 mm. For the fi

2、rst two types (solitary and multifocal nodular types), the CT findings included low density lesions with clear margins on non-contrast scans, centripetal sntrptl enhancement in arterial phase, and homogeneous enhancement in the portal venous vins and delay phases. The fidings of non-contrast MRI sca

3、ns for these two types included low signal intensity on T1-weighted images, heterogeneous high signal intensity on T2-weighted images, and heterogeneous high signal intensity on diffusion-weighted images.The lesions were predominantly located in submarginal areas. On contrastenhanced MRI, the fiding

4、s for the first two types included peripheral ring-like enhancement with a central low signal intensity (black target-like sign) and a central enhanced core surrounded by a low signal intensity halo (white targetlike sign).,2,.,The findings for the third HEH type (diffuse type) on CT and MRI scans i

5、ncluded low density or heterogeneous signal intensity lesions involving regions of part or the whole liver, coalescent lesions (strip-like sign), and gradual enhancement along central vessels (lollipop sign).,3,.,Hepatic epithelioid hemangioendothelioma (HEH) is a rare vascular tumor of endothelial

6、endi:lrl origin with low- to intermediate-grade malignancy . Previous studies have revealed that HEH tends to coalesce into diffuse lesions in the late stages of the disease .Conventional treatments of HEH include surgical resection or liver transplantation. Previously, certain novel systemic drugs

7、have been used in the treatment of HEH, including thalidomide ldmad沙利度胺and sorafenib 索拉芬妮. The prognosis pr:gnoss for patients with HEH is considered much more favorable compared with that of other hepatic malignancies, with a 5-year survival rate of 4355% .,4,.,A 45-year-old male with solitary nodu

8、lar-type HEH. (A) The HEH nodule (straight arrow) had a low-density appearance on non-contrast computed tomography imaging, and a liver abscess (curved arrow) with tiny air bubbles was found adjacent to the HEH lesion. .,5,.,Figure 2. A-58-year female with multifocal nodular-type HEH. (A) On T2-weig

9、hted imaging, HEH nodules (straight arrow) showed a two-layered target-likeappearance with central high signal intensity; the high-signal intensity core was surrounded by a peripheral prfrl slightly hyperintense halo. The lesions were predominantly located in submarginal areas of the liver (curved a

10、rrow). (B) On TI-weighted imaging, the lesions had a low-signal intensity appearance. (C) On contrast-enhanced T1-weighted fat-suppressed images, the lesions exhibited gradual ring-like enhancement (arrow).,6,.,Figure 3. A 72yearold male with multifocal nodulartype HEH. (A) On T2weighted imaging, th

11、e coalescent lesions, locating in submarginal areas, showed white targetlike and striplike signs (arrow); the twolayered target appearance was formed with a highsignal intensity core and peripheral slightly hyperintense halo. (B) On diffusion-weighted imaging, the lesions showed a high signal intens

12、ity halo outside of the central slightly high-signal intensity core (arrow). (C and D) On dynamic contrast-enhanced TI-weighted images with fat-suppression, HEH lesions showed gradual peripheral ring-like enhancement patterns with central low signal intensity in the arterial to delay phases; frequen

13、tly the enhanced lesions were surrounded by a thin, hypointense ring in the portal or delay phases (black target-like sign) (arrow). Peripheral distribution and capsular retraction was also observed (curved arrow).,7,.,Figure 4. A 47-year-old male with multifocal nodular-type HEH. (A) Heterogeneous

14、(混雜)high-signal intensity masses were located in the right lobe surrounded by several nodules on T2-weighted imaging (arrow). (B) The lesions showed slightly high intensity with a high-intensity rim on diffusion-weighted imaging. (C) The lesions showed homogeneous(均勻) low signal intensity on non-con

15、trast TI weighted-imaging.,8,.,(D) The lesions showed peripheral nodular enhancement in the arterial phase and gradual heterogeneous enhancement in the portal venous and delay phases (arrow). hetrdi:nis trnzint prekm (E) The transient abnormal perfusion in peripheral liver parenchyma was visualized

16、in arterial phase and disappeared in portal venous phase (black arrow). (F) A hepatic vein was found within the lesions (lollipop sign) (curved arrow).,9,.,Figure 5. A 65-year-old female with diffuse-type HEH. (A) The CT features included diffuse low density lesions with minimal residual parts of no

17、rmal liver parenchyma (curved arrow). prekm (B and C) The MRI features included heterogeneous high signal intensity on T2-weighted imaging with patchy uniform signal intensity inside the lesions. (B) Nodules and masses (star) coexisted in this case. Nodules showed a target-like sign (curved arrow) a

18、nd heterogeneous enhancement on contrast-enhanced scan. (C) Masses exhibited strip-like enhancement along central vessels in the arterial phase, and gradual enhancement in the portal venous and delay phases (straight arrow).,10,.,Previously, HEH was frequently misdiagnosed as metastasis or, more rar

19、ely, as primary tumor of the liver, based on imaging and pathology . Pathological studies have indicated that myxoidmksd, hyaloplasm halplzmand fiber compositions are present in the central part of HEH, which determine the appearance of CT and MRI scans and the enhancement patterns of the tumor . The peripheral region of the lesion, which is rich in tumor cells, demonstrates rim enhancement on the arterial phase, while the central part, which is rich in fiber composition, demonstrated delayed enha

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